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CTCF protects cohesin^STAG1 from WAPL.

Hundreds of proteins are involved in the DNA damage response but only three sensors for DSB were known but now SIRT6 is identified as a fourth DSB sensor.

Poly-PR and poly-GR interact with importin β, disrupt importin-cargo loading, and inhibit nuclear import in permeabilized cells in a manner that can be rescued by RNA.

Plant reticulons bind Atg8 under ER stress to promote reticulophagy and ameliorate ER stress in the maize endosperm.

Microtubules orchestrate wound repair and innate immune response in the Caenorhabditis elegans epidermis.

The RAB-28 GTPase regulates ciliary extracellular vesicle shedding, which may be important for neuron-glia communication.

An experimentally constrained multiscale mathematical model predicts that branched actin networks self-organize at endocytic sites and bend to produce force, which was verified with cryo-electron tomography of intact cells.

Death receptor 5 can directly sense misfolded proteins downstream of the endoplasmic reticulum to provide a quality control mechanism that executes apoptosis and prevents further production of misfolded proteins.

Chemically distinct opioid ligands promote selective protein recruitment by opioid receptors in intact cells.

EDEM2 containing mannosidase homology domain functions as an initiator of endoplasmic reticulum-associated degradation of misfolded glycoproteins by conversion of Man₉GlcNAc₂ to Man₈GlcNAc₂, only when complexed with TXNDC11 containing thioredoxin-like domains.