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Treacle condensation, driven by alternating charge blocks, facilitates interactions with transcription factors to spatially segregate ribosomal RNA synthesis and processing, while also recruiting TOPBP1 for activation of the rDNA damage response.

Neuronal Calcium Sensor-1 (NCS1) is a protein that captures the preciliary vesicle in the early step of the cilium formation.

Comprehensive analyses of localization, hierarchy, and function of the proteins located at the distal appendages of the centriole.

Transition from healthy to diseased state is a cell-type-specific process, influenced by neighboring cells and resulting in functionally meaningful differences between pulmonary artery adventitial fibroblasts and smooth muscle cells.

In pulmonary hypertension, a combination of metabolic and mechanical dysfunction leads to irreversible vascular damage.

Identifying the regulators of a non-genetic mechanism (ERCYS) that is constitutively activated in cancer cells to provide pro-survival properties.

Single-cell imaging and mass spectrometry data reveal adenosine in the DNA of mammalian cells can be methylated by METTL3 to form N6-methyladenosine in response to DNA damage.

Molecularly defined serotonin (enterochromaffin) cells of the gut lining were distinguished by single-cell expression analysis, in situ hybridization, and immunohistochemistry into 14 topographically organized clusters, with features implying that they are functionally distinct classes of serotonin cells.

Small-molecule agonists of transcription factor EB alleviate Niemann–Pick disease type C via promoting lysosomal function.