Browse our latest Cell Biology articles

A giant multifunctional protein complex mediates mating-type recognition through a non-ligand–receptor mechanism in a multisexual species.

SNAP25 disease mutations within the synaptotagmin interface impair vesicle priming and cause uncontrolled spontaneous release due to enhanced SNARE:SNARE interactions, whereas a mutation within the SNARE-bundle increases the fusion energy barrier.

A genetically encoded fluorescent biosensor reveals temporally resolved changes to aspartate concentration during genetic, pharmacological, and nutritional manipulations.

A hitherto unknown role of Piezo1 mechanosensors in chemotactic migration of human T cells is identified, linking focal adhesion formation to integrin recruitment.

A Topbp1 mutant mouse reveals a non-canonical role for the ATR-TOPBP1 signaling axis in meiosis, separating ATR signaling and meiotic sex chromosome inactivation from sex body formation.

Computational modeling combined with biophysical and cellular experiments reveal that rapid binding to incomplete, partial microtubule binding sites facilitates tracking of the end-binding protein EB1 with growing microtubule plus-ends.

The plant developmental regulator GNOM performs its unique function from the cell periphery, through sequence features present in all its domains, and not by the control of endocytosis.

Deletion of β-catenin in Col2⁺ progenitor cells shifts their commitment from osteoblasts to adipocytes, leading to a full spectrum of disease phenotype of glucocorticoid-induced osteonecrosis of the femoral head in adult mice.

First systemic lysosomal proteomes in association with longevity and tissue specificity in C. elegans uncover lysosomal heterogeneity across multiple scales and provide valuable resources for understanding how lysosomes modulate signal transduction, organelle communication, tissue physiology, and organism longevity.