Endophilin A1 at postsynaptic sites promotes inhibitory postsynaptic organization through interaction with gephyrin to maintain E/I balance, which is essential for the suppression of epilepsy susceptibility.
Alexander N Kapustin, Sofia Serena Tsakali ... Catherine M Shanahan
Fibronectin triggers secretion of extracellular vesicles carrying collagen VI that regulate smooth muscle cell adhesion and migration during vascular repair and atherogenesis.
Akinori Endo, Chikage Takahashi ... Yukiko Yoshida
Ubiquitin accumulated on damaged lysosomes activates TAB–TAK1–IKK–NF-κB axis and remodels proteome through gene expression for cell survival and cell-cell communication.
Veronica H Ryan, Sydney Lawton ... Michael Emmerson Ward
Protein, but not mRNA, levels of neurodegenerative disease-associated protein TDP-43 are decreased upon knockdown of BORC, a complex that is required for the anterograde transport of lysosomes.
A neutrality index identifies mox-YG as a minimally cytotoxic protein, enabling ultra-high expression and uncovering key physiological consequences of protein burden.
Changes of the chromatin structure suggests how the fate selector transcription factors are activated and how they guide differentiation of GABAergic and glutamatergic neurons in the anterior brainstem.