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    1. Cell Biology
    2. Neuroscience

    Maintenance of neuronal TDP-43 expression requires axonal lysosome transport

    Veronica H Ryan, Sydney Lawton ... Michael Emmerson Ward
    Protein, but not mRNA, levels of neurodegenerative disease-associated protein TDP-43 are decreased upon knockdown of BORC, a complex that is required for the anterograde transport of lysosomes.
    1. Cell Biology
    2. Genetics and Genomics

    Impact of maximal overexpression of a non-toxic protein on yeast cell physiology

    Yuri Fujita, Shotaro Namba ... Hisao Moriya
    A neutrality index identifies mox-YG as a minimally cytotoxic protein, enabling ultra-high expression and uncovering key physiological consequences of protein burden.
    1. Cell Biology
    2. Evolutionary Biology

    Horizontally transferred cell-free chromatin particles function as autonomous ‘satellite genomes’ and vehicles for transposable elements within host cells

    Soumita Banerjee, Soniya Sanjay Shende ... Indraneel Mittra
    Uptake of cell-free chromatin particles released from dying cells and carrying non-coding DNA could redefine mammalian genomics.
    1. Cell Biology
    2. Developmental Biology

    Gene regulatory mechanisms guiding bifurcation of inhibitory and excitatory neuron lineages in the mouse anterior brainstem

    Sami Kilpinen, Lassi Virtanen ... Juha Partanen
    Changes of the chromatin structure suggests how the fate selector transcription factors are activated and how they guide differentiation of GABAergic and glutamatergic neurons in the anterior brainstem.
    1. Cell Biology
    2. Physiology

    Cellular characterization of the mouse collecting lymphatic vessels reveals that lymphatic muscle cells are the innate pacemaker cells

    Scott D Zawieja, Grace A Pea ... Michael J Davis
    Lymphatic muscle cells, but not CD34+ adventitial cells, exhibited pacemaker behaviors including pressure-dependent depolarization, pressure-dependent calcium mobilization during diastole, and propagated contraction waves induced by focal, optogenetic depolarization via channel rhodopsin2.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Dissecting organoid-bacteria interaction highlights decreased contractile force as a key factor for heart infection

    Anheng Wang, Jiaxian Wang ... Chunming Wang
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Cell Biology

    Deletion of sulfate transporter SUL1 extends yeast replicative lifespan via reduced PKA signaling instead of decreased sulfate uptake

    Juan Long, Meng Ma ... Jing Yang
    SUL1 deletion extends lifespan via PKA-MSN2 pathways, underscoring nutrient signaling over sulfate transport in aging regulation.
    1. Cell Biology
    2. Immunology and Inflammation

    β-glucan reprograms macrophages to attenuate efferocytosis of cancer cells

    Alexandros Chatzis, Jakub Lukaszonek ... Ioannis Kourtzelis
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Enalapril mitigates senescence and aging-related phenotypes in human cells and mice via pSmad1/5/9-driven antioxidative genes

    Wencong Lyu, Haochen Wang ... Wei Tao
    Enalapril combats the effects of senescence by activating the pSmad1/5/9–antioxidative gene axis, enhancing antioxidative defenses and promoting cell proliferation, thereby supporting healthy aging.
    1. Cell Biology

    C-terminal tagging, transmembrane domain hydrophobicity, and an ER retention motif influence the secretory trafficking of the inner nuclear membrane protein emerin

    Jessica Mella, Regan F Volk ... Abigail Buchwalter
    The inner nuclear membrane protein emerin readily traffics through the secretory pathway via its hydrophobic transmembrane domain when tagged with C-terminal GFP.
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