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RSPO-ZNRF3/RNF43 specifically regulates the degradation of FZD5/8 under Wnt stimulation independently of DVL.

High-content high-resolution microscopy coupled with deep learning-based analysis reveals novel phenotypes at the single-cell level during Shigella infection.

Megakaryocytes form a 3D cage of laminin and collagen IV that stabilizes them within their vascular niche, while β1/β3 integrins and MMP are key regulators that assist megakaryocyte maturation and intravasation.

Endophilin A1 at postsynaptic sites promotes inhibitory postsynaptic organization through interaction with gephyrin to maintain E/I balance, which is essential for the suppression of epilepsy susceptibility.

Fibronectin triggers secretion of extracellular vesicles carrying collagen VI that regulate smooth muscle cell adhesion and migration during vascular repair and atherogenesis.

Long-term 17α-estradiol modulates aged male hypothalamic function via HPG axis and energy metabolism, mitigating aging-related neuronal changes.

Ubiquitin accumulated on damaged lysosomes activates TAB–TAK1–IKK–NF-κB axis and remodels proteome through gene expression for cell survival and cell-cell communication.

Sulfation is required for organizing the apical extracellular matrix during tubular organ formation.

A novel YAP/TEAD regulatory mechanism by NSP13 provides molecular insights into Hippo-YAP regulation after SARS-CoV-2 infection.