Open science and consensus antibody validation protocols can identify high-quality, renewable antibodies for the ~50% of the human proteome currently covered, enabling robust and reproducible biomedical research.
On different bacterial diets, which also serve as different environments for Caenorhabditis elegans, specific sensory neurons and insulin-like peptides integrate food-derived signals to modulate oocyte biology, and hence reproduction.
The photoreceptor tetraspanin protein ROM1 contributes to the formation of light-sensitive 'disc' membranes, but it can be functionally replaced by an excess of its homologous binding partner PRPH2.
Cyclin D1 protein stability is regulated by ubiquitin-proteasome mechanism mediated by multiple E3 ligases, including newly identified Keap1, DDB2, and WSB2.
A strategy to identify high-quality commercially available antibodies for research reveals extensive use of non-specific antibodies and offers solutions for future large-scale testing.
