A study in mice reveals key interactions between proteins involved in fibroblast growth factor signaling and how they contribute to distinct stages of eye lens development.
Paul Richard J Yulo, Nicolas Desprat ... Heather L Hendrickson
Fitness defects arising from deletion of the gene encoding the bacterial equivalent of actin (mreB) are readily compensated by mutations affecting cell wall synthesis.
It was revealed that phosphorylation of the DNA repair enzyme PNKP at threonine 118 by CDK is required for DNA replication through the gap filling of Okazaki fragments.
Oxidized LDL synergizes with angiotensin II to amplify Gq signaling via the AT1-LOX1 receptor complex, revealing a novel mechanism driving renal dysfunction in hypertension and dyslipidemia.
ORMDL3 promotes RIG-I degradation to suppress type I interferon signaling pathway and antiviral immune response, highlighting ORMDL3 as a potential therapeutic target in viral infection and cancer immunotherapy.
