M Gartz Hanson, Jonathan J Wilde ... Lee Niswander
A mouse model of human muscle myopathy is used to provide mechanistic insight, identify possible biomarkers of disease, and suggest possible therapeutic strategies to alleviate muscle weakness.
Two membrane proteins that belong to a new type of cell-surface receptor mediate the transmembrane signaling for a secreted factor that has broad therapeutic value.
The integrated quantification of spontaneous dynamic cell-cell force transmissions at both multi-cellular and subcellular scales enables spatiotemporal correlations of stress distribution with biomolecules in small cell clusters.
Angela Castanieto, Michael J Johnston, Todd G Nystul
The specification of cell polarity is essential for self-renewal and the segregation of stem-cell and daughter-cell fates in an epithelial stem cell lineage.
Hirohito Shimizu, Johann Schredelseker ... Jau-Nian Chen
Enhancing mitochondrial Ca2+ uptake effectively suppresses aberrant Ca2+ induced arrhythmogenic events in zebrafish, mouse and human cardiomyocytes, demonstrating a critical role for mitochondria in the regulation of cardiac rhythmicity.
W Christopher Risher, Sagar Patel ... Cagla Eroglu
Spines with multiple excitatory contacts are potential sites for competition between thalamic and cortical axons, which is regulated by the astrocytes through the secreted synaptogenic protein hevin.