Browse our latest Cell Biology articles

Page 292 of 330
    1. Cell Biology

    GnT1IP-L specifically inhibits MGAT1 in the Golgi via its luminal domain

    Hung-Hsiang Huang, Antti Hassinen ... Pamela Stanley
    GnT1IP-L is a membrane bound glycoprotein that interacts with MGAT1 in the Golgi, but not in the endoplasmic reticulum, to regulate complex N-glycan synthesis.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Structured illumination with particle averaging reveals novel roles for yeast centrosome components during duplication

    Shannon Burns, Jennifer S Avena ... Sue L Jaspersen
    Visualization of yeast spindle pole proteins using a new microscopy method shows that assembly into the nuclear membrane occurs at the same time as duplication.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Distinct transcriptional responses elicited by unfolded nuclear or cytoplasmic protein in mammalian cells

    Yusuke Miyazaki, Ling-chun Chen ... Thomas J Wandless
    A new unfolded protein response has been discovered that is distinct from the heat shock response and protects mammalian cells from proteotoxic stress.
    1. Cell Biology
    2. Immunology and Inflammation

    Small molecule inhibition of Csk alters affinity recognition by T cells

    Boryana N Manz, Ying Xim Tan ... Arthur Weiss
    The T cell response, especially to weak agonists, is enhanced by acute Csk inhibition.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Specific cancer-associated mutations in the switch III region of Ras increase tumorigenicity by nanocluster augmentation

    Maja Šolman, Alessio Ligabue ... Daniel Abankwa
    Rare mutations in the switch III region of Ras can increase its nanoscale clustering, which enhances effector recruitment and downstream signaling.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Aven recognition of RNA G-quadruplexes regulates translation of the mixed lineage leukemia protooncogenes

    Palaniraja Thandapani, Jingwen Song ... Stéphane Richard
    Arginine methylation regulates mRNA translation of key protooncogenes via an RGG/RG motif-containing protein called Aven.
    1. Cell Biology
    2. Cancer Biology

    BAG2 promotes tumorigenesis through enhancing mutant p53 protein levels and function

    Xuetian Yue, Yuhan Zhao ... Wenwei Hu
    Overexpression of BAG2—a novel mutant p53 binding protein—in tumors inhibits MDM2-mediated mutant p53 degradation, which leads to the accumulation of mutant p53 protein and promotes tumorigenesis.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Wss1 metalloprotease partners with Cdc48/Doa1 in processing genotoxic SUMO conjugates

    Maxim Y Balakirev, James E Mullally ... Keith D Wilkinson
    Wss1 is both a metalloprotease and SUMO ligase found in association with Cdc48 and Doa1 and accumulating in the vacuole upon DNA damage.
    1. Cell Biology
    2. Plant Biology

    SnRK1-triggered switch of bZIP63 dimerization mediates the low-energy response in plants

    Andrea Mair, Lorenzo Pedrotti ... Markus Teige
    The transcription factor bZIP63 is a key regulator of the starvation response in the model plant Arabidopsis thaliana and is directly targeted by the kinase SnRK1.