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How nuclear pore complexes establish their permeability barrier has been a long-standing question; now, this process can be reconstituted by a surprisingly simple and rapid self-assembly of Nup98 FG domains into selective FG phases.

The architecture of the bacterial cytokinetic ring in cells and in artificial liposome reconstitutions has been described using electron microscopy, leading to a mechanism of constriction.

Building on previous work (Jinek et al., 2013), we report a simple and robust system to achieve high fidelity and high efficiency (30% of homologous recombination) genome engineering by homology-directed repair pathway in human cells using cell cycle synchronization and timed delivery of Cas9 ribonucleoprotein complexes.

Building on previous work (Ly et al., 2014), we show that elutriated cells and arrested cells have similar patterns of DNA content and cyclin expression: however, a large fraction of the proteome changes detected in arrested cells are found to reflect arrest-specific responses rather than physiological cell cycle regulation.

Selective docking of HAC1 mRNA on Ire1 clusters at a site separate from the Ire1 RNase domain is key for endoplasmic reticulum stress signaling.

LINKIN and three of its interactors-RUVBL1, RUVBL2, and α-tubulin-are required for cells to migrate together during organogenesis.

During early embryogenesis of the sea urchin, asymmetrical positioning of the dorsal/ventral organizer relies upon the suppression of organizer activities in dorsal blastomeres by the Hbox12 homeodomain-containing repressor.

Oculocutaneous albinism II (OCA2) contributes to a melanosome-specific anion channel that modulates organellar pH and is critical for melanin synthesis.

Spontaneous fusion of vesicles at synapses is regulated independently of fusion triggered by action potentials, adding to evidence that the two types of fusion have distinct functions.

Local inward plasma membrane deformations caused by actomyosin-dependent contraction trigger the dynamic recruitment of a curvature-sensitive actin-regulatory protein, which represents a receptor-independent auto-regulatory mechanism to control local actin polymerization dynamics at the plasma membrane.