The jellyfish embryonic body axis is globally coordinated by conserved planar cell polarity (PCP) mechanisms and oriented by localised Wnt3 in two steps, highlighting PCP’s role in animal axis evolution.
MYL3 is identified as a novel receptor enabling nervous necrosis virus (NNV) entry via macropinocytosis, revealing a therapeutic target for combating NNV outbreaks in aquaculture.
Self-supervised deep learning models can accurately perform 3D segmentation of cell nuclei in complex biological tissues, enabling scalable analysis in settings with limited or no ground truth annotations.
Polysome formation within the nucleoid and repulsion between these major cytoplasmic components provide a self-organizing mechanism for chromosome segregation and modulation of its timing across growth rates in Escherichia coli.
AlphaFold-guided in vitro and in vivo analyses establish the mechanism of ULK complex formation and provide a structural basis for understanding its role in mammalian autophagy initiation.
Subcellular sequestration of caspase near membrane-associated proteins enables its non-lethal activation, which modulates neuronal function and innate olfactory behavior in the adult Drosophila olfactory receptor neurons.
Phosphorylation of the kinesin-2 motor protein’s elbow region by NEKL-3 kinase maintains autoinhibition, enabling its transport to cilia for sensory function.
San Pin Steve Wu, Elvis Quiroz ... Francesco J DeMayo
Genome-wide epigenetic profiling reveals chromatin regions in the human myometrium involved in functional regulation and hormonal control during pregnancy.
