Browse our latest Cell Biology articles

Cell biological approaches and spatiotemporally resolved proteome profiling demonstrate that the chemokine receptor CCR7 can activate G proteins after being internalized into endosomes, from where it regulates Rac1-dependent chemotaxis.

A catalytic growth model in a shared enzyme pool explains robust centrosome size equality and size scaling, offering a unifying model for centrosome maturation dynamics across diverse organisms.

By regulating the chromosome axis component and meiotic HORMAD, HIM-3, the conserved AAA-ATPase PCH-2 controls the number and distribution of meiotic recombination events.

Ankle2 functions as a regulatory subunit of PP2A and interacts with the endoplasmic reticulum protein Vap33 to promote the dephosphorylation of BAF as part of nuclear reassembly after mitosis.

A computational systems biology approach identifies a gene network module associated with single-cell mechanical phenotype changes across diverse mouse and human systems, with implications for on-demand engineering of cell stiffness.

Ezrin controls endo-lysosomal signaling by maintaining TSC inhibition through EGFR signaling, activating mTORC1, and inhibiting lysosomal function, unveiling a critical endosome–lysosome network essential for autophagy and cellular homeostasis.

3D light-sheet imaging identifies the location and metabolic sensitivity of β-cell subpopulations that lead and coordinate islet Ca²⁺ oscillations.

Compounds that activate integrated stress response kinases inhibit mitochondrial fragmentation induced by chemical or genetic insults, indicating that targeting this pathway offers opportunities to mitigate mitochondrial fragmentation in diverse diseases.

Functional subpopulations of β-cells emerge to control pulsative insulin secretion in the pancreatic islets of mice through calcium oscillations.