There is an ongoing need for researchers and all stakeholders to better understand issues surrounding antibody characterization to improve the quality and reproducibility of research that employs these reagents.
Birol Cabukusta, Shalom Borst Pauwels ... Jacques Neefjes
Lipid transfer proteins at the ER-Golgi interface synchronize intracellular lipid flows through the secretory pathway, ensuring the asymmetric lipid composition of the plasma membrane.
Georg Kislinger, Gunar Fabig ... Martina Schifferer
An array tomography and electron tomography hybrid approach based on coated plastic tape as support advances ultrastructural analysis of biological phenomena that require cell- and tissue-level contextualization of the finest subcellular textures.
Centrosomes in mammalian cells are required for timely completion of mitosis and in their absence the spindle assembly checkpoint is required to delay mitosis and allow assembly of a functional spindle.
Elizabeth A Beath, Cynthia Bailey ... Francis J McNally
Limiting cytoplasmic streaming contributes to maintaining spatial separation of the sperm contents from the female meiotic spindle after fertilization.
Calreticulin, beyond its known role as a chaperone, also serves as an endoplasmic reticulum repressor of ATF6⍺, selectively regulating one arm of the unfolded protein response.
Alex Weiss, Cassandra D'Amata ... Madeline N Hayes
Modeling glioblastoma using expression of relevant human oncogenes in syngeneic zebrafish offers a powerful platform for current and future biological discovery, diagnostics, and therapeutic testing in an intact tumor microenvironment.
