Browse our latest Cell Biology articles

Page 67 of 315
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Snf1/AMPK fine-tunes TORC1 signaling in response to glucose starvation

    Marco Caligaris, Raffaele Nicastro ... Claudio De Virgilio
    Discovery of new Snf1/AMPK targets in the TORC1 pathway highlights the complex, multilayered crosstalk between major signaling pathways in the regulation of nutrient deprivation sensing.
    1. Cell Biology
    2. Physics of Living Systems

    Condensates: When fixation creates fiction

    Judith Miné-Hattab
    A chemical regularly used to image cells can dramatically alter the way cellular compartments called condensates look under the microscope.
    Version of Record
    Insight
    1. Cell Biology

    Impaired iron recycling from erythrocytes is an early hallmark of aging

    Patryk Slusarczyk, Pratik Kumar Mandal ... Katarzyna Mleczko-Sanecka
    A decline in iron-recycling functions of the splenic red pulp macrophages early during aging is driven by iron loading and involves their damage and a loss in red blood cell clearance capacity.
    1. Cell Biology

    A concerted mechanism involving ACAT and SREBPs by which oxysterols deplete accessible cholesterol to restrict microbial infection

    David B Heisler, Kristen A Johnson ... Arun Radhakrishnan
    An essential role for ACAT in conferring 25HC-mediated protection against bacterial and viral infection has been uncovered.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Creating an atlas of the bone microenvironment during oral inflammatory-related bone disease using single-cell profiling

    Yi Fan, Ping Lyu ... Chenchen Zhou
    Single-cell sequencing of the alveolar bone marrow of apical periodontitis reveals the cellular and molecular composition of the microenvironment and highlights an osteogenic potential within mesenchymal stem cells of inflammatory-related bone diseases.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    N-terminal domain on dystroglycan enables LARGE1 to extend matriglycan on α-dystroglycan and prevents muscular dystrophy

    Hidehiko Okuma, Jeffrey M Hord ... Kevin P Campbell
    N-terminal domain of dystroglycan enables like-acetylglucosaminyl transferase to elongate matriglycan on α-dystroglycan and prevent skeletal muscle pathophysiology.
    1. Cell Biology
    2. Neuroscience

    Growth cone advance requires EB1 as revealed by genomic replacement with a light-sensitive variant

    Alessandro Dema, Rabab Charafeddine ... Torsten Wittmann
    Genome editing to insert a light-sensitive dimerization module directly into the EB1 microtubule plus end adaptor gene in human induced pluripotent stem cells enables local and acute optogenetic EB1 inactivation highlighting microtubule functions in developing neuronal growth cones.
    1. Cell Biology

    Nucleotide binding is the critical regulator of ABCG2 conformational transitions

    Zsuzsanna Gyöngy, Gábor Mocsár ... Katalin Goda
    The conformational switch of ABCG2 from the high substrate affinity inward-facing to a low substrate affinity outward-facing state is induced by nucleotide binding and accelerated by transported substrates.
    1. Cell Biology
    2. Immunology and Inflammation

    Transiently heritable fates and quorum sensing drive early IFN-I response dynamics

    Laura C Van Eyndhoven, Vincent PG Verberne ... Jurjen Tel
    Early IFN-I response dynamics are initiated in only fractions of cells, of which their epigenetic profile is transiently heritable and subject to the effects of quorum sensing.
    1. Cell Biology
    2. Neuroscience

    Optogenetics and electron tomography for structure-function analysis of cochlear ribbon synapses

    Rituparna Chakrabarti, Lina María Jaime Tobón ... Carolin Wichmann
    Ultrastructural analysis of optogenetically stimulated inner hair cell ribbon synapses reveals normally sized synaptic vesicles and enhanced vesicle docking at the active zone membrane.