Browse our latest Cell Biology articles

Page 67 of 320
    1. Cell Biology

    Autofluorescence imaging permits label-free cell type assignment and reveals the dynamic formation of airway secretory cell associated antigen passages (SAPs)

    Viral S Shah, Jue Hou ... Jayaraj Rajagopal
    Autofluorescence imaging permits label-free cell type identification in live airway tissue and reveals the dynamic formation of airway secretory cell associated antigen passages.
    1. Cell Biology
    2. Developmental Biology

    Inactivation of Invs/Nphp2 in renal epithelial cells drives infantile nephronophthisis like phenotypes in mouse

    Yuanyuan Li, Wenyan Xu ... Zhaoxia Sun
    Genetic and chemical genetic analysis pinpoint defective epithelial cells as the driver for NPHP like phenotypes in Invs mutants, demonstrate genetic interaction between Invs and Ift88 and identify the HDAC inhibitor valproic acid as a suppressor for Invs mutant phenotypes.
    1. Cell Biology
    2. Neuroscience

    Axon guidance genes modulate neurotoxicity of ALS-associated UBQLN2

    Sang Hwa Kim, Kye D Nichols ... Randal S Tibbetts
    Axon guidance genes are conserved regulators of neurodegeneration in Drosophila melanogaster and human inducible motor neuron models of UBQLN2-associated amyotrophic lateral sclerosis.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Calaxin stabilizes the docking of outer arm dyneins onto ciliary doublet microtubule in vertebrates

    Hiroshi Yamaguchi, Motohiro Morikawa, Masahide Kikkawa
    Zebrafish genetics and sperm cryo-electron tomography reveal a novel function of Calaxin as a docking complex component stabilizing the outer arm dynein onto the ciliary doublet microtubule.
    1. Cell Biology
    2. Neuroscience

    Activity regulates a cell type-specific mitochondrial phenotype in zebrafish lateral line hair cells

    Andrea McQuate, Sharmon Knecht, David W Raible
    The highly metabolically active hair cells of the zebrafish lateral line have a distinct mitochondrial phenotype consisting of small mitochondria apically and large, networked mitochondrion basally, demonstrating a nonuniform mitochondrial architecture that is sculpted by cellular activity.
    1. Cell Biology
    2. Developmental Biology

    Svep1 is a binding ligand of Tie1 and affects specific aspects of facial lymphatic development in a Vegfc-independent manner

    Melina Hußmann, Dörte Schulte ... Stefan Schulte-Merker
    Tie1 is a binding partner for Svep1 in zebrafish and humans, and both genes (but not Tie2) are required during zebrafish lymphangiogenesis especially for the facial lymphatics, which in part develop independent of Vegfc.
    1. Cell Biology
    2. Developmental Biology

    Pleiotropic effects of BAFF on the senescence-associated secretome and growth arrest

    Martina Rossi, Carlos Anerillas ... Myriam Gorospe
    The levels of the cytokine BAFF increase across senescence paradigms, in turn triggering a secretory phenotype in some senescent cells and activating p53 in other senescent cells.
    1. Cell Biology
    2. Neuroscience

    Regulation of different phases of AMPA receptor intracellular transport by 4.1N and SAP97

    Caroline Bonnet, Justine Charpentier ... Françoise Coussen
    Biochemistry, videomicroscopy, and immunocytochemistry reveal differential roles of GluA1/4.1N and GluA1/SAP97 interactions on GluA1 intracellular transport and exocytosis in basal transmission and during cLTP in cultured hippocampal neurons.
    1. Cell Biology
    2. Developmental Biology

    AGS3 antagonizes LGN to balance oriented cell divisions and cell fate choices in mammalian epidermis

    Carlos P Descovich, Kendall J Lough ... Scott E Williams
    A proper balance of planar and perpendicular balances is critical to establishing proper epidermal architecture and is mediated by the opposing activities of LGN and its enigmatic paralog AGS3.
    1. Cell Biology

    Syncytin-mediated open-ended membrane tubular connections facilitate the intercellular transfer of cargos including Cas9 protein

    Congyan Zhang, Randy Schekman
    A human endogenous fusogen, syncytin, which facilitates placental cell-cell fusion during early embryonic development, mediates the formation of open-ended membrane tubular connections between other cell types that efficiently promotes the intercellular transfer of cytoplasmic cargos including Cas9 protein and organelles.