Browse our latest Chromosomes and Gene Expression articles

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    1. Chromosomes and Gene Expression

    Rif2 protects Rap1-depleted telomeres from MRX-mediated degradation in Saccharomyces cerevisiae

    Fernando Rodrigo Rosas Bringas, Sonia Stinus ... Michael Chang
    Telomere-specific depletion of Rap1, the main sequence-specific telomere-binding protein in Saccharomyces cerevisiae, can be tolerated due to the presence of secondary telomere capping mechanisms, which may help explain the rapid evolution of budding yeast telomeres.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    Establishment of developmental gene silencing by ordered polycomb complex recruitment in early zebrafish embryos

    Graham JM Hickey, Candice L Wike ... Bradley R Cairns
    Zebrafish early embryos initially package their developmental genes and enhancers in 'active' chromatin that subsequently receives polycomb repressive complex 1 (PRC1)-mediated histone H2A ubiquitylation, which confers silencing/poising – prior to Aebp2-PRC2-guided H3K27me3 addition.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Analysis of long and short enhancers in melanoma cell states

    David Mauduit, Ibrahim Ihsan Taskiran ... Stein Aerts
    Multi-level massively parallel reporter assays (H3K27ac, ATAC and short tiles) in a panel of melanoma cell lines, together with a deep learning model, reveal location, multiplicity and grammar of subtype specific enhancers.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    RNase III-mediated processing of a trans-acting bacterial sRNA and its cis-encoded antagonist

    Sarah Lauren Svensson, Cynthia Mira Sharma
    Functional characterization of a pair of cis-encoded antisense RNAs reveals a role for RNase III and antisense regulation in the biogenesis and regulatory activity of a bacterial virulence factor-regulating small RNA.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Serine ADP-ribosylation marks nucleosomes for ALC1-dependent chromatin remodeling

    Jugal Mohapatra, Kyuto Tashiro ... Glen Liszczak
    A technology to produce homogenously poly-ADP-ribosylated proteins reveals key molecular mechanisms that govern ATP-dependent chromatin remodeling activity at DNA damage sites.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Reversible phosphorylation of cyclin T1 promotes assembly and stability of P-TEFb

    Fang Huang, Trang TT Nguyen ... Koh Fujinaga
    Cyclin T1 phosphorylation determines levels of P-TEFb via stabilizing interactions between cyclin T1 and CDK9.
    1. Chromosomes and Gene Expression
    2. Evolutionary Biology

    High rates of evolution preceded shifts to sex-biased gene expression in Leucadendron, the most sexually dimorphic angiosperms

    Mathias Scharmann, Anthony G Rebelo, John R Pannell
    In the dioecious plant genus Leucadendron, shifts to sex-biased gene expression occurred predominantly in genes with ancestrally high rates of expression evolution, and were not correlated with morphology.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Sumoylation of the human histone H4 tail inhibits p300-mediated transcription by RNA polymerase II in cellular extracts

    Calvin Jon A Leonen, Miho Shimada ... Champak Chatterjee
    Chemically sumoylated histone H4 shows negative biochemical crosstalk with gene-activating histone acetylation and methylation marks, and directly inhibits RNA polymerase II-mediated gene transcription.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Pathway dynamics can delineate the sources of transcriptional noise in gene expression

    Lucy Ham, Marcel Jackson, Michael PH Stumpf
    There are fundamental limits to what can be learned about the origins of transcriptional noise from gene expression data alone, which can be overcome by simultaneously quantifying the abundances of linked molecular species.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Local chromatin fiber folding represses transcription and loop extrusion in quiescent cells

    Sarah G Swygert, Dejun Lin ... Toshio Tsukiyama
    Using a yeast model of quiescence, it was demonstrated that dramatic changes in local chromatin fiber folding can occur under physiological conditions to regulate cellular processes.