Browse our latest Chromosomes and Gene Expression articles

Combining ribosome profiling and RNA sequencing illuminates novel features of porcine reproductive and respiratory syndrome virus gene expression, including the regulation of polyprotein stoichiometry through temporal modulation of ribosomal frameshifting and the synthesis of non-canonical transcripts.

The efficiency with which ribosomes shift reading frames when decoding viral RNA may change over the course of an infection.

New open-source method contains all the tools for extracting open chromatin or RNA from thousands of single cells in parallel for <5% of the cost of state-of-the-art commercial alternatives, paving the way for whole-tissue atlasing and new protocol development.

Dynamic interactions of core clock molecules are quantitively measured and mathematically modelled to reveal the hidden role of PER:CRY complexes in enhancing the mobility of CLOCK:BMAL1 to move to new DNA sites.

A robust computational pipeline for alternative splicing analysis is developed and applied to large-scale cell atlases, overcoming technical challenges and making results available for the scientific community to explore via public interactive browsers.

The hunchback transcription features are compatible with an equilibrium model with a short decay length Bicoid activity gradient as the sole source of positional information, while Zelda and Hunchback speed-up the process by different means.

A novel co-translational mechanism continuously adjusts the expression levels of ribosomal proteins Rpl3 and Rpl4 to their consumption during ribosome synthesis by regulating the abundance of their mRNAs.

Bioinformatics analyses reveal that the Krüppel-associated box domain zinc finger proteins are associated with DNA methylation of retroelements in human primordial germ cells which highlight potential molecular mechanisms for the regulation of retroelements in human male germ cells.

Animal survival in hypoxia requires the classical hypoxia-inducible factor (HIF) signalling pathway, but in the nematode worm C. elegans, a new signalling pathway involving the nuclear receptor NHR-49/PPARalpha is as important for hypoxia survival as the HIF pathway.

The general transcription factor TFIIH complex promotes the establishment and maintenance of chromosome structure during mitosis by altering the chromatin environment to allow for proper loading and function of the condensin complexes on chromatin.