Browse our latest Computational and Systems Biology articles

Neural computations necessary for efficient control of saccades capture the phenomenon of saccadic suppression, which suggests that neural resources are shared for perception and control.

Collision between ribosomes can cause dissociation of stalled ribosomes from messenger RNAs during the process of mRNA translation.

Conserved contacts on cognate ligands trigger an induced fit pathway that confers selective promiscuity to PD-1, a flexible regulatory protein and promising anticancer target.

Experimental evolution shows that when selection acts on two traits constrained by a trade-off, the direction of phenotypic evolution depends on the environment.

A new statistical approach identifies non-coding regulatory regions of genes as driver candidates with recurrent mutations across cancer samples that associate with gene expression, patient survival or mutational phenotype.

Nonlinear H₂O₂ scavenging by peroxiredoxins drives acquired stress resistance and replicative lifespan hormesis.

The maintenance of memory CD4 T cells in mice relies on a continual and strikingly high level of replenishment from naive precursors, and older memory T cells may resist the influx of newer ones.

The resurrection of ancient ancestral intrinsically disordered proteins reveals the evolution of a protein-protein interaction in molecular detail.

DeBias is a generic method to decompose and quantify the confounding, global factors and direct interactions of pairwise interacting variables.

Mathematical modeling reveals that long-term immunological memory is maintained in a manner that is even more dynamic than previously thought.