Browse our latest Computational and Systems Biology articles

A computational framework called TissueMiner, complete with tutorials, will allow a wide range of users to perform quantitative multiscale analysis of tissue morphogenesis.

A model of purely competitive ecological dynamics is shown to be equivalent to adaptive evolution of a single individual, suggesting a new way to formalize the "superorganism" metaphor.

Over 7,000 novel translated sequences have been identified from human cells, including several hundred in annotated noncoding RNA, pseudogenes and de novo assembled transcripts.

Different types of epigenetic DNA modifications affect the likelihood of cytosine mutations in cancer.

Pre-existing enhancers interpret T cell signaling strength in an analogue manner to direct quantitative changes in gene expression within the context of an overall digital response.

Computational and theoretical models reveal mechanisms by which protein compartments assemble around enzymes and reagents to facilitate reactions in bacteria, allowing the identification of strategies for reengineering such compartments as customizable nanoreactors.

Realistic reaction-diffusion signaling networks that include cell-autonomous factors can robustly form self-organizing spatial patterns for any combination of diffusion coefficients without requiring differential diffusivity.

Analysing Myosin II unipolar planar polarisation with high spatial and temporal resolution during Drosophila axis extension reveals how tissue boundaries drive polarized cell intercalation while limiting cell mixing.

Mitochondrial respiratory chain dysfunction inhibits mitochondrial one-carbon metabolism, impairing cellular nucleotide biosynthesis.