Browse our latest Computational and Systems Biology articles

Page 118 of 130
    1. Physics of Living Systems
    2. Computational and Systems Biology

    Overall energy conversion efficiency of a photosynthetic vesicle

    Melih Sener, Johan Strumpfer ... Klaus Schulten
    The overall energy conversion efficiency is calculated for a bacterial vesicle that harvests solar energy for ATP production on the basis of an atomic-detail structural model.
    1. Computational and Systems Biology
    2. Neuroscience

    Decoupling kinematics and mechanics reveals coding properties of trigeminal ganglion neurons in the rat vibrissal system

    Nicholas E Bush, Christopher L Schroeder ... Mitra JZ Hartmann
    Primary sensory neurons of the rat whisker system encode contact with objects in terms of the forces exerted on whiskers, rather than the induced whisker movements.
    1. Structural Biology and Molecular Biophysics
    2. Computational and Systems Biology

    Molecular dynamics-based refinement and validation for sub-5 Å cryo-electron microscopy maps

    Abhishek Singharoy, Ivan Teo ... Klaus Schulten
    New hybrid structure determination methods leveraging the inherent biophysical properties of a macromolecule through molecular dynamics simulations provide accurate and cost-efficient ways of achieving atomic structures from high resolution cryo-electron density maps.
    1. Computational and Systems Biology
    2. Neuroscience

    CO2-evoked release of PGE2 modulates sighs and inspiration as demonstrated in brainstem organotypic culture

    David Forsberg, Zachi Horn ... Eric Herlenius
    Novel brainstem organotypic cultures that generate rhythmic respiratory motor activity reveal the neural networks that control breathing and a new pathway in the hypercapnic response.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Lineage tracing of human B cells reveals the in vivo landscape of human antibody class switching

    Felix Horns, Christopher Vollmers ... Stephen R Quake
    A comprehensive map of patterns of class switching reveals how antibodies of every class are created in humans.
    1. Computational and Systems Biology
    2. Ecology

    Place recognition using batlike sonar

    Dieter Vanderelst, Jan Steckel ... Marc W Holderied
    Echolocating bats may recognize locations in the environment (and navigate to them) by remembering the specific echo signature of those locations.
    1. Cell Biology
    2. Computational and Systems Biology

    Global, quantitative and dynamic mapping of protein subcellular localization

    Daniel N Itzhak, Stefka Tyanova ... Georg HH Borner
    A spatial proteomics method can capture physiological protein subcellular localization changes in response to a stimulus, resolving all major organelles.
    1. Computational and Systems Biology

    Neural oscillations as a signature of efficient coding in the presence of synaptic delays

    Matthew Chalk, Boris Gutkin, Sophie Denève
    Neural oscillations are a necessary consequence of efficient coding of sensory signals by a spiking neural network, limited by synaptic delays and noise.
    1. Computational and Systems Biology
    2. Neuroscience

    Integrative neuromechanics of crawling in D. melanogaster larvae

    Cengiz Pehlevan, Paolo Paoletti, L Mahadevan
    An integrative model of coordinated crawling in fruit fly maggots links neuromuscular dynamics to body-substrate mechanics in the presence of proprioceptive feedback.
    1. Computational and Systems Biology
    2. Chromosomes and Gene Expression

    Metabolic network rewiring of propionate flux compensates vitamin B12 deficiency in C. elegans

    Emma Watson, Viridiana Olin-Sandoval ... Albertha JM Walhout
    The roundworm C. elegans transcriptionally activates five genes comprising an alternate propionate breakdown pathway when dietary vitamin B12 is low or when the canonical pathway is compromised.