Browse our latest Computational and Systems Biology articles

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    1. Computational and Systems Biology
    2. Neuroscience

    Action detection using a neural network elucidates the genetics of mouse grooming behavior

    Brian Q Geuther et al.
    A machine learning method for action detection is developed and applied toward mouse grooming behavior.
    1. Computational and Systems Biology
    2. Neuroscience

    Graphical-model framework for automated annotation of cell identities in dense cellular images

    Shivesh Chaudhary et al.
    Unbiased and automatic annotation using structured prediction framework with efficiently built data-driven atlases is more accurate than registration-based methods for cell identifications in dense images and enables fast whole-brain analysis.
    1. Cell Biology
    2. Computational and Systems Biology

    CEM500K, a large-scale heterogeneous unlabeled cellular electron microscopy image dataset for deep learning

    Ryan Conrad, Kedar Narayan
    'Cellular Electron Microscopy 500,000 images' (CEM500K) is a highly heterogeneous, information-rich, non-redundant, unlabeled EM dataset curated to pre-train DL algorithms for better model generalization on EM segmentation tasks.
    1. Computational and Systems Biology
    2. Neuroscience

    Uncovering the computational mechanisms underlying many-alternative choice

    Armin W Thomas et al.
    A comparison of different computational models reveals that looking behavior, during value-based choices from 9, 16, 25, or 36 snack foods, actively influences the subjective values of the available alternatives.
    1. Computational and Systems Biology
    2. Medicine

    Identification of human glucocorticoid response markers using integrated multi-omic analysis from a randomized crossover trial

    Dimitrios Chantzichristos et al.
    A human experimental model for physiological glucocorticoid exposure and glucocorticoid withdrawal identifies a multi-omic cluster, including microRNA miR-122-5p and metabolites, associated with glucocorticoid-responsive genes.
    1. Computational and Systems Biology

    Control and regulation of acetate overflow in Escherichia coli

    Pierre Millard et al.
    Elucidating the control and regulation of acetate overflow in E. coli reveals that acetate is not only an end-product but also a co-substrate and a global regulator of glucose metabolism.
    1. Computational and Systems Biology
    2. Developmental Biology

    Single-cell transcriptomics of the Drosophila wing disc reveals instructive epithelium-to-myoblast interactions

    Nicholas J Everetts et al.
    A single-cell atlas of the developing Drosophila wing disc at two time points enables a detailed understanding of the signals exchanged between different cell populations during development.
    1. Cell Biology
    2. Computational and Systems Biology

    Quantifying absolute gene expression profiles reveals distinct regulation of central carbon metabolism genes in yeast

    Rosemary Yu et al.
    Global gene expression control mechanisms are modeled using a large dataset consisting of absolute-quantitative proteomics, transcriptomics, and partial metabolomics of Saccharomyces cerevisiae at a wide range of growth conditions.