Browse our latest Computational and Systems Biology articles

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    1. Computational and Systems Biology
    2. Physics of Living Systems

    Non-equilibrium strategies enabling ligand specificity by signaling receptors

    Andrew Goetz, Jeremy Barrios ... Purushottam D Dixit
    Non-equilibrium thermodynamics allows signaling networks to signal downstream of certain ligands but avoid signaling from others.
    1. Computational and Systems Biology
    2. Neuroscience

    Homophilic wiring principles underpin neuronal network topology in vitro

    Danyal Akarca, Alexander WE Dunn ... Manuel Schröter
    Functional connectivity in rodent and human neuronal cultures is best explained by homophilic wiring rules, in which neurons preferentially form connections depending on spatial proximity and shared connectivity patterns, suggesting a unifying principle across scales.
    1. Computational and Systems Biology
    2. Medicine

    Critique of impure reason: Unveiling the reasoning behaviour of medical large language models

    Shamus Zi Yang Sim, Tyrone Chen
    A survey of reasoning behaviour in medical large language models uncovers emerging trends, highlights open challenges, and introduces theoretical frameworks that enhance reasoning behaviour transparency, ultimately fostering greater trust among clinicians, developers, and patients in their deployment.
    1. Developmental Biology
    2. Computational and Systems Biology

    Anti-resonance in developmental signaling regulates cell fate decisions

    Samuel J Rosen, Olivier Witteveen ... Maxwell Z Wilson
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Genetics and Genomics
    2. Computational and Systems Biology

    Human-specific lncRNAs contributed critically to human evolution by distinctly regulating gene expression

    Jie Lin, Yujian Wen ... Hao Zhu
    Revised
    Reviewed Preprint v4
    Updated
    • Valuable
    • Incomplete
    1. Computational and Systems Biology

    Subtle methodological variations substantially impact correlation test results in ecological time series

    Caroline Cannistra, Linh Hoang ... Wenying Shou
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Computational and Systems Biology

    Twist is the key to the gating of mechanosensitive ion channel NOMPC

    Jingze Duan, Chen Song
    Rotation of the transient receptor potential (TRP) domain appears to be a universal mechanism for gating of the TRP channel family, including the mechanosensitive ion channel NOMPC.
    1. Structural Biology and Molecular Biophysics
    2. Computational and Systems Biology

    Decoding molecular mechanisms for loss-of-function variants in the human proteome

    Matteo Cagiada, Nicolas Jonsson, Kresten Lindorff-Larsen
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    • Solid
    1. Neuroscience
    2. Computational and Systems Biology

    Anti-diuretic hormone ITP signals via a guanylate cyclase receptor to modulate systemic homeostasis in Drosophila

    Jayati Gera, Marishia Agard ... Meet Zandawala
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Cell Biology
    2. Computational and Systems Biology

    Extrusion-modulated DnaA activity oscillations coordinate DNA replication with biomass growth

    Dengjin Li, Hai Zheng ... Chenli Liu
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
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