Browse our latest Computational and Systems Biology articles

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    1. Computational and Systems Biology
    2. Physics of Living Systems

    Landscape of epithelial–mesenchymal plasticity as an emergent property of coordinated teams in regulatory networks

    Kishore Hari, Varun Ullanat ... Mohit Kumar Jolly
    Investigation of regulatory network topology reveals latent design principles of multistable phenotypic landscape.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Transcriptome-wide association study and eQTL colocalization identify potentially causal genes responsible for human bone mineral density GWAS associations

    Basel Maher Al-Barghouthi, Will T Rosenow ... Charles R Farber
    Systems genetics approaches identify potentially causal bone mineral density genes.
    1. Computational and Systems Biology

    A tug of war between filament treadmilling and myosin induced contractility generates actin rings

    Qin Ni, Kaustubh Wagh ... Garegin A Papoian
    Actin networks form clusters under myosin-induced contractility, while high actin filament treadmilling speed can reshape actin networks into ring-like structures with lower mechanical energy.
    1. Computational and Systems Biology
    2. Neuroscience

    High-throughput automated methods for classical and operant conditioning of Drosophila larvae

    Elise C Croteau-Chonka, Michael S Clayton ... Kristina T Klein
    A novel high-throughput FPGA-based multi-animal tracking and training system was used to demonstrate trace and operant conditioning in Drosophila larvae.
    1. Computational and Systems Biology
    2. Neuroscience

    Mesoscale cortex-wide neural dynamics predict self-initiated actions in mice several seconds prior to movement

    Catalin Mitelut, Yongxu Zhang ... Timothy H Murphy
    Mouse self-initiated behaviors can be identified seconds prior to action and have similar neuro-dynamical structure to neural dynamics underlying human voluntary actions supporting the use of mouse models in self-initiated and volitional action research.
    1. Neuroscience
    2. Computational and Systems Biology

    The individuality of shape asymmetries of the human cerebral cortex

    Yu-Chi Chen, Aurina Arnatkevičiūtė ... Kevin M Aquino
    Asymmetries between the shape of the left and right human cortex are highly unique to individuals, akin to a neuroanatomical fingerprint, related to cognitive function, and primarily driven by person-specific environmental influences.
    1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    Deep mutational scanning and machine learning reveal structural and molecular rules governing allosteric hotspots in homologous proteins

    Megan Leander, Zhuang Liu ... Srivatsan Raman
    Deep mutational scanning of homologous proteins shows conservation in allosteric mechanisms but differences in molecular details within the protein family.