Browse our latest Computational and Systems Biology articles

Page 2 of 131
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Selective suppression and biasing of chemokine receptors CCR9 and ACKR4 through targeting CCL25 with de novo miniproteins

    Bas de Boer, Thomas D Lamme ... Christopher T Schafer
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Computational and Systems Biology
    2. Neuroscience

    Olfactory combinatorial coding supports risk–reward decision-making in Caenorhabditis elegans

    Md Zubayer Hossain Saad, William G Ryan ... Bruce A Bamber
    An odorant is encoded in the periphery as independent inputs of attractive and repulsive valence, which are then integrated and balanced to drive overall chemotactic behavior.
    1. Computational and Systems Biology

    AI in Science: The 42 problem in AI-assisted research

    Giovanni Spitale, Federico Germani
    Large language models excel at producing answers, but an answer severed from its question and context may lack meaning.
    1. Neuroscience
    2. Computational and Systems Biology

    A theory-guided model maps four recurrent modes of fear-goal arbitration across learning and relapse in rats

    Bin Yin, Jiaojiao Rao, XT (XiaoTian) Wang
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Computational and Systems Biology

    Penumbria: Advanced 3D cell segmentation for biomedical imaging

    Laurids Stockert, Joseph Donovan, Herwig Baier
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Obtaining maximum information from colony counts with REPOP

    Pedro Pessoa, Carol Yunxiao Slayton ... Steve Presse
    Conventional colony counting obscures bacterial population structure by conflating biological heterogeneity with stochastic noise from dilution and plating, which can be separated by explicitly modeling the measurement process.
    1. Computational and Systems Biology

    Role of desolvation on biomolecular liquid–liquid phase separation

    Kai Zhang, Zhiyu Peng ... Wei Wang
    A desolvation-aware coarse-grained framework enables efficient and physically realistic modeling of biomolecular phase separation by capturing water-mediated effects on phase behavior, dense-phase packing, conformational reorganization, and dynamics.
    1. Genetics and Genomics
    2. Computational and Systems Biology

    Evolutionary remodeling of non-canonical ORF translation in mammals

    Yue Chang, Tianyu Lei ... Hong Zhang
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Convincing