Browse our latest Computational and Systems Biology articles

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    1. Computational and Systems Biology
    2. Neuroscience

    Asymmetric retinal direction tuning predicts optokinetic eye movements across stimulus conditions

    Scott C Harris, Felice A Dunn
    Retinal physiology and anatomy and visual behavior reveal how sensory circuits in the retina can shape an organism’s eye movements over a range of ethologically relevant stimulus conditions.
    1. Computational and Systems Biology

    Learning predictive cognitive maps with spiking neurons during behavior and replays

    Jacopo Bono, Sara Zannone ... Claudia Clopath
    Predictive cognitive maps can be learned during behavior and replays using in spiking neurons.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Network-based multi-omics integration reveals metabolic at-risk profile within treated HIV-infection

    Flora Mikaeloff, Marco Gelpi ... Ujjwal Neogi
    Multi-omics-driven patient stratification identify at-risk profile of metabolic complications in people living with HIV on suppressive therapy that need clinical attention.
    1. Cell Biology
    2. Computational and Systems Biology

    Information transfer in mammalian glycan-based communication

    Felix F Fuchsberger, Dongyoon Kim ... Christoph Rademacher
    The information stored in glycans is interpreted and read by cell surface-exposed lectin receptors, and with information theory, the formal framework is set for how to analyze such complex single-cell data.
    1. Cancer Biology
    2. Computational and Systems Biology

    Interplay of adherens junctions and matrix proteolysis determines the invasive pattern and growth of squamous cell carcinoma

    Takuya Kato, Robert P Jenkins ... Erik Sahai
    Cancer invasion occurs with different molecular and spatial patterns, thin invading strands are associated with mesenchymal cell features, such as low cell-cell adhesion, while broad strands are favoured for lymph node metastasis and require high matrix proteolysis and cell-cell adhesions.
    1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    Drug specificity and affinity are encoded in the probability of cryptic pocket opening in myosin motor domains

    Artur Meller, Jeffrey M Lotthammer ... Gregory R Bowman
    A cryptic pocket in the myosin motor domain selectively opens in molecular dynamics simulations, and the probability of pocket opening is predictive of how potently a compound will inhibit a particular myosin motor.
    1. Cancer Biology
    2. Computational and Systems Biology

    Pan-cancer association of DNA repair deficiencies with whole-genome mutational patterns

    Simon Grund Sørensen, Amruta Shrikhande ... Jakob Skou Pedersen
    1. Computational and Systems Biology
    2. Epidemiology and Global Health

    National Institutes of Health research project grant inflation 1998 to 2021

    Michael S Lauer, Joy Wang, Deepshikha Roychowdhury
    National Institutes of Health (NIH) grants have evolved over time, with a greater proportion of funds going to solicited projects, but inflation-adjusted costs have remained relatively stable following a brief increase during the NIH-doubling (1998-2003).
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Synthetic analysis of chromatin tracing and live-cell imaging indicates pervasive spatial coupling between genes

    Christopher H Bohrer, Daniel R Larson
    The physical distance between genes in individual cells is the major factor driving co-transcriptional bursts, showing a significant degree of correlation for distances below 400 nm.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Coevolution-based prediction of key allosteric residues for protein function regulation

    Juan Xie, Weilin Zhang ... Luhua Lai
    Key allosteric residues are predicted based on sequence coevolution analysis, which serves as guidelines for allosteric drug design and optimization.