Browse our latest Computational and Systems Biology articles

Page 2 of 120
    1. Computational and Systems Biology
    2. Cancer Biology

    Drug combination prediction for cancer treatment using disease-specific drug response profiles and single-cell transcriptional signatures

    Daniel Osorio, Parastoo Shahrouzi ... Marieke L Kuijjer
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Immunology and Inflammation
    2. Computational and Systems Biology

    Tissue resident memory CD4+ T cells are sustained by site-specific levels of self-renewal and continuous replacement

    Jodie Chandler, M Elise Bullock ... Andrew J Yates
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Identification and classification of ion-channels across the tree of life: Insights into understudied CALHM channels

    Rahil Taujale, Sung Jin Park ... Natarajan Kannan
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    • Inadequate
    1. Neuroscience
    2. Computational and Systems Biology

    A SMARTTR workflow for multi-ensemble atlas mapping and brain-wide network analysis

    Michelle Jin, Simon O Ogundare ... Christine A Denny
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Computational and Systems Biology

    Semantical and geometrical protein encoding toward enhanced bioactivity and thermostability

    Yang Tan, Bingxin Zhou ... Liang Hong
    The novel pre-training framework integrating sequential and geometric encoders significantly enhances protein engineering by accurately predicting variant effects and thermostability, outperforming existing zero-shot learning methods with minimal computational cost.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Interpreting roles of mutations associated with the emergence of S. aureus USA300 strains using transcriptional regulatory network reconstruction

    Saugat Poudel, Jason Hyun ... Bernhard O Palsson
    Transcriptional regulatory network models can aid in identifying candidate genes associated with the target phenotype in bacterial genome-wide association studies.
    1. Computational and Systems Biology

    Barcode-free multiplex plasmid sequencing using Bayesian analysis and nanopore sequencing

    Masaaki Uematsu, Jeremy M Baskin
    SAVEMONEY is a computational tool that guides users to mix plasmids prior to nanopore sequencing, reducing the effective cost of whole-plasmid sequencing to below that of Sanger sequencing.
    1. Computational and Systems Biology

    Unsupervised Representation Learning of C. elegans Poses and Behavior Sequences From Microscope Video Recordings

    Maurice Deserno, Katarzyna Bozek
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete