Browse our latest Computational and Systems Biology articles

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    1. Computational and Systems Biology

    Generative modeling for RNA splicing predictions and design

    Di Wu, Natalie Maus ... Yoseph Barash
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Computational and Systems Biology

    A mathematical model that predicts human biological age from physiological traits identifies environmental and genetic factors that influence aging

    Sergiy Libert, Alex Chekholko, Cynthia Kenyon
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Immunology and Inflammation
    2. Computational and Systems Biology

    Thrifty wide-context models of B cell receptor somatic hypermutation

    Kevin Sung, Mackenzie M Johnson ... Frederick A Matsen
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Computational and Systems Biology

    Untargeted pixel-by-pixel metabolite ratio imaging as a novel tool for biomedical discovery in mass spectrometry imaging

    Huiyong Cheng, Dawson Miller ... Qiuying Chen
    A novel R ratiometric imaging tool provides enhanced knowledge obtained from conventional spatial data profiling technologies.
    1. Neuroscience
    2. Computational and Systems Biology

    MorphoCellSorter: An Andrews plot-based sorting approach to rank microglia according to their morphological features

    Sarah Benkeder, Son-Michel Dinh ... Jean-Christophe Comte
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Solid
    1. Computational and Systems Biology

    Passive shaping of intra- and intercellular m6A dynamics via mRNA metabolism

    David Dierks, Ran Shachar ... Schraga Schwartz
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Exploring the repository of de novo-designed bifunctional antimicrobial peptides through deep learning

    Ruihan Dong, Rongrong Liu ... Cheng Zhu
    Peptides designed by artificial intelligence restrict both drug-resistant bacteria and rapidly evolving viruses.
    1. Immunology and Inflammation
    2. Computational and Systems Biology

    Tissue resident memory CD4+ T cells are sustained by site-specific levels of self-renewal and replacement from precursors

    Jodie Chandler, M Elise Bullock ... Andrew J Yates
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling
    1. Computational and Systems Biology
    2. Neuroscience

    A statistical framework for analysis of trial-level temporal dynamics in fiber photometry experiments

    Gabriel Loewinger, Erjia Cui ... Francisco Pereira
    A fiber photometry analysis framework based on functional mixed models enhances the detection of effects by testing signal-variable associations at each trial timepoint and accounting for between-animal heterogeneity.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Allosteric modulation by the fatty acid site in the glycosylated SARS-CoV-2 spike

    A Sofia F Oliveira, Fiona L Kearns ... Adrian J Mulholland
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
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