Browse our latest Computational and Systems Biology articles

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    1. Computational and Systems Biology
    2. Neuroscience

    Rotational dynamics in motor cortex are consistent with a feedback controller

    Hari Teja Kalidindi et al.
    Integrating circuit-level theories about population dynamics in motor cortex with behavioral-level theories about motor control.
    1. Computational and Systems Biology
    2. Neuroscience

    Motor Control: Sensory feedback can give rise to neural rotations

    Omid G Sani, Maryam M Shanechi
    Investigating how an artificial network of neurons controls a simulated arm suggests that rotational patterns of activity in the motor cortex may rely on sensory feedback from the moving limb.
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    1. Computational and Systems Biology
    2. Genetics and Genomics

    Science Forum: Author-sourced capture of pathway knowledge in computable form using Biofactoid

    Jeffrey V Wong et al.
    Biofactoid is a tool that enables researchers to capture information about molecular interactions in a form that is both human-readable and machine-computable, thereby allowing this information to be integrated into public knowledge-bases and to be widely disseminated.
    1. Cancer Biology
    2. Computational and Systems Biology

    Investigating the replicability of preclinical cancer biology

    Timothy M Errington et al.
    A project to repeat experiments from high-impact papers in cancer biology found that the effects observed in replications were frequently weaker than, or inconsistent with, the effects reported in the original papers.
    1. Computational and Systems Biology
    2. Medicine

    Topological network analysis of patient similarity for precision management of acute blood pressure in spinal cord injury

    Abel Torres-Espín et al.
    The application of topological network analysis on multicenter high-frequency intra-operative physiology data discovers a precise range of blood pressure during surgery predicting poor recovery in spinal cord injury patients.
    1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    Markov state models of proton- and pore-dependent activation in a pentameric ligand-gated ion channel

    Cathrine Bergh et al.
    Computational models of gating processes in an ion channel show how stability shifts upon ligand-binding and mutations are reproduced, which highlights mechanistic details and proposes a new role for symmetry in gating.
    1. Computational and Systems Biology
    2. Neuroscience

    Circadian Rhythm: How neurons adjust to diurnality

    Gabriele Andreatta, Charles N Allen
    Being active during the day requires a slow-closing ion channel that dampens the activity of neurons in a specific area of the brain.
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    1. Computational and Systems Biology
    2. Neuroscience

    Daily electrical activity in the master circadian clock of a diurnal mammal

    Beatriz Bano-Otalora et al.
    Circadian control of neuronal excitability in the master circadian clock of a diurnal mammal as revealed by whole-cell recording and mathematical modeling.