Browse our latest Computational and Systems Biology articles

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    1. Computational and Systems Biology
    2. Medicine

    A computational model predicts sex-specific responses to calcium channel blockers in mammalian mesenteric vascular smooth muscle

    Gonzalo Hernandez-Hernandez, Samantha C O'Dwyer ... Colleen E Clancy
    A computer model predicts different mechanisms of blood pressure regulation and effective hypertensive therapy for males and females, thereby serving as a foundational tool for improved treatment precision.
    1. Computational and Systems Biology

    The genetic and dietary landscape of the muscle insulin signalling network

    Julian van Gerwen, Stewart WC Masson ... David E James
    Genetic background and dietary environment interact to reshape metabolic signalling networks, and the resulting signalling diversity can illuminate regulatory mechanisms of complex traits.
    1. Immunology and Inflammation
    2. Computational and Systems Biology

    Transformer-based spatial-temporal detection of apoptotic cell death in live-cell imaging

    Alain Pulfer, Diego Ulisse Pizzagalli ... Santiago Fernandez Gonzalez
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    A kinase to cytokine explorer to identify molecular regulators and potential therapeutic opportunities

    Marina Chan, Yuqi Kang ... Taranjit S Gujral
    KinCytE is a web-based platform that explores kinase-cytokine-driven signaling and its relevance to understanding and treating diseases linked to disruptions in these pathways.
    1. Computational and Systems Biology

    Affected cell types for hundreds of Mendelian diseases revealed by analysis of human and mouse single-cell data

    Idan Hekselman, Assaf Vital ... Esti Yeger-Lotem
    The PrEDiCT scheme infers disease-affected cell types from the expression of disease-associated genes in single-cell expression atlases, thereby providing cellular context and enhancing mechanistic understanding for 328 Mendelian diseases.