Olga Ibañez-Solé, Alex M Ascensión ... Ander Izeta
An increase in transcriptional noise generally assumed to characterize aged cells and tissues is shown to derive instead from technical and biological issues that underlie single-cell RNA sequencing experiments.
Valentyna Zinchenko, Johannes Hugger ... Anna Kreshuk
Unsupervised machine learning on the ultrastructure and shape of cells in volume electron microscopy yields a compact representation of cellular morphology that complements genetics-based cell type characterisation.
Mutations conferring resistance to Escherichia coli against the chemotherapy drug gemcitabine can have opposite effects on bacterial drug degradation and therefore can increase or decrease the chemotherapy load on neighboring cancer cells.
DeCalciOn is a low-cost open-source hardware system for real-time in vivo calcium imaging that offers capabilities for online decoding of neural population activity and delivery of short latency closed-loop feedback in freely behaving animals.
Marina Ainciburu, Teresa Ezponda ... Felipe Prosper
Single-cell transcriptomics reveals altered pathways, gene expression dynamics, and activation of transcriptional programs in human early hematopoiesis during healthy aging and myelodysplastic syndromes.
Anastasia O Smirnova, Anna M Miroshnichenkova ... Alexander Komkov
A hallmark property of non-functional clonotypes was used to develop a universal and fully computational method for detection and correction of multiplex PCR-specific quantitative bias in adaptive immune receptor repertoire.