Browse our latest Computational and Systems Biology articles

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    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    A recursive pathway for isoleucine biosynthesis arises from enzyme promiscuity

    Vittorio Rainaldi, Stefano Donati ... Nico J Claassens
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Computational and Systems Biology

    Raw signal segmentation for estimating RNA modification from Nanopore direct RNA sequencing data

    Guangzhao Cheng, Aki Vehtari, Lu Cheng
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Cancer Biology
    2. Computational and Systems Biology

    BEHAV3D Tumor Profiler to map heterogeneous cancer cell behavior in the tumor microenvironment

    Emilio Rios-Jimenez, Anoek Zomer ... Maria Alieva
    BEHAV3D Tumor Profiler enables researchers without computational expertise to uncover heterogeneous cell behaviors and explore their relationships with microenvironmental features in intravital microscopy data.
    1. Neuroscience
    2. Computational and Systems Biology

    Absence of Systematic Effects of Internalizing Psychopathology on Learning Under Uncertainty

    Muhammad H Satti, Katharina Wille ... Rasmus Bruckner
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Computational and Systems Biology

    A network regularized linear model to infer spatial expression pattern for single cell

    Chaohao Gu, Hu Chen, Zhandong Liu
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Convincing
    1. Computational and Systems Biology

    TrueProbes: Quantitative Single-Molecule RNA-FISH Probe Design Improves RNA Detection

    Jason J Hughes, Benjamin K Kesler ... Gregor Neuert
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Neuroscience
    2. Computational and Systems Biology

    Deep Neural Networks to Register and Annotate Cells in Moving and Deforming Nervous Systems

    Adam A Atanas, Alicia Kun-Yang Lu ... Steven W Flavell
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    • Incomplete
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Pan-tissue transcriptome analysis reveals sex-dimorphic human aging

    Siqi Wang, Danyue Dong ... Zefeng Wang
    Widespread sex-dimorphic transcriptomic changes during human aging in pan-tissues scale reveal distinct molecular aging trajectories and potential links to age-related disease vulnerability.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Squidly: Enzyme Catalytic Residue Prediction Harnessing a Biology-Informed Contrastive Learning Framework

    William JF Rieger, Mikael Boden ... Ariane Mora
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Neuroscience
    2. Computational and Systems Biology

    Comparing the outputs of intramural and extramural grants funded by National Institutes of Health

    Xiang Zheng, Qiyao Yang ... B Ian Hutchins
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
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