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    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Allosteric modulation by the fatty acid site in the glycosylated SARS-CoV-2 spike

    A Sofia F Oliveira, Fiona L Kearns ... Adrian J Mulholland
    Equilibrium and nonequilibrium simulations uncover how the fatty acid site in the SARS-CoV-2 spike modulates protein dynamics, revealing its intricate allosteric connections and the impact of glycans on these networks.
    Version of Record
    Short Report
    • Valuable
    • Convincing
    1. Neuroscience
    2. Computational and Systems Biology

    Predictive modeling of hematoma expansion from non-contrast computed tomography in spontaneous intracerebral hemorrhage patients

    Natasha Ironside, Kareem El Naamani ... ERICH Investigators and the VISTA-ICH collaboration
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Computational and Systems Biology

    A network regularized linear model to infer spatial expression pattern for single cell

    Chaohao Gu, Hu Chen, Zhandong Liu
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Computational and Systems Biology

    Redox regulation and dynamic control of brain-selective kinases BRSK1/2 in the AMPK family through cysteine-based mechanisms

    George N Bendzunas, Dominic P Byrne ... Natarajan Kannan
    Characterization of redox-active cysteines illuminates the understudied regulatory mechanisms of brain-selective kinases.
    1. Computational and Systems Biology

    Perturbation-response analysis of in silico metabolic dynamics in nonlinear regime: Hard-coded responsiveness in the cofactors and network sparsity

    Yusuke Himeoka, Chikara Furusawa
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Solid
    1. Neuroscience
    2. Computational and Systems Biology

    Olfactory combinatorial coding supports risk-reward decision making in C. elegans

    Md Zubayer Hossain Saad, William G Ryan ... Bruce A Bamber
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Ecology
    2. Computational and Systems Biology

    How bats exit a crowded colony when relying on echolocation only - a modeling approach

    Omer Mazar, Yossi Yovel
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Neuroscience
    2. Computational and Systems Biology

    Fast and slow synaptic plasticity enables concurrent control and learning

    Brendan A Bicknell, Peter E Latham
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Overflow metabolism originates from growth optimization and cell heterogeneity

    Xin Wang
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Convincing
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Loss of CTRP10 results in female obesity with preserved metabolic health

    Fangluo Chen, Dylan C Sarver ... G William Wong
    Mice lacking the secreted hormone, CTRP10, represent a unique female model of obesity with preserved metabolic health, highlighting sex-specific mechanisms that uncouple obesity from metabolic dysfunction.
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