Browse our latest Computational and Systems Biology articles

A mathematical model of colorectal cancer initiation shows that a change in cells’ kinetic parameters due to aspirin can account for an observed reduction in advanced adenoma age- incidence in patients treated with aspirin.

Computed decisions degrade in working memory in a manner that depends on one of two strategies used to store relevant information as revealed by mathematical analysis of behavioral response patterns.

The GPCR-G protein coupling map and selectivity insights will catalyze advances in receptor research, cellular signaling, and drug discovery exploiting G protein signaling bias to design safer drugs.

An improved conditional gene-based association analysis framework guided by multiple variant-gene mapping strategies was built and evaluated based on its performance in predicting the potential susceptibility isoforms, genes, and tissues of schizophrenia.

Mapping spike patterns from a small identified circuit reveals the diversity and complexity of circuit dynamics across animals and in response to perturbations.

Multicellular systems exhibiting a wide variety of behaviors, including logic gates, band-pass filtering, and bistability, are constructed from a fixed vocabulary of input-output strains through model-guided design demonstrating predictable composability, tunability, and extendability.

A non-invasive animal monitoring system paired with a custom analysis pipeline allows organism-level aging to be studied with improved throughput, resolution, and physiological scope while reducing the activation energy that comes with highly specialized challenge-based procedures.

A robust computational pipeline for alternative splicing analysis is developed and applied to large-scale cell atlases, overcoming technical challenges and making results available for the scientific community to explore via public interactive browsers.

Modelling differential roles for identified dopaminergic and output neurons of the fruit fly mushroom bodies, combined with a novel dopaminergic plasticity rule, explains neural and behavioural phenomena in olfactory learning tasks.

The gender gap in publication productivity has increased during the COVID-19 pandemic, with potential implications for the careers of women working in research.