Browse our latest Computational and Systems Biology articles

A genome scale model of Brugia malayi metabolism illustrates a dynamic reliance on energy production pathways across its life cycle and identifies new drugs with experimentally supported anti-parasitic properties.

Gene expression analysis reveals a novel, integrated molecular mechanism for much of the pathogenesis of COVID-19 that provides therapeutic intervention points that can be addressed with existing approved pharmaceuticals.

An elaborated bat-predator model shows that even in high bat-densities, bats can successfully catch flying insects and that changing their signals’ frequency is not necessary for dealing with sensory interference.

De novo protein nanoparticles were designed from scratch to present viral glycoprotein antigens, providing a systematic way to study the influence of antigen presentation geometry on immune response.

Analysis and modelling of sensorimotor neural activity shows how ongoing plasticity and appropriately tuned weights can cope with substantial ongoing changes in the neural code.

A mathematical model describes the function of dopaminergic neurons in both learning and action planning.

Diagnosing the presence and clinical significance of prostate cancer can be achieved using AI-based analysis of peripheral blood natural killer (NK) cell subset profiles.

Mirror neurons, including corticospinal neurons, in primary motor cortex of macaque monkeys, clearly dissociate between execution and observation of grasping actions while ventral premotor cortex (F5) maintains a similar representation.

Synthetic biology experiments show that MYC is a general transcription amplifier acting at two or more sites in the transcription-cycle and that MYC-turnover contributes to its activity.

A mathematical modelling approach to understanding zebrafish stripe pattern formation exemplifies a biological rule-set sufficient to generate wild-type and a diverse range of mutant patterns.