Browse our latest Computational and Systems Biology articles

Page 74 of 128
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Modeling transfer of vaginal microbiota from mother to infant in early life

    Martin Steen Mortensen, Morten Arendt Rasmussen ... Søren Johannes Sørensen
    Modeling weighted transfer ratios enable statistical analysis of maternal–infant transfer at a more general level and can indicate whether any transfer is persistent, transient, or originates from alternate sources.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Longitudinal high-throughput TCR repertoire profiling reveals the dynamics of T-cell memory formation after mild COVID-19 infection

    Anastasia A Minervina, Ekaterina A Komech ... Mikhail V Pogorelyy
    Longitudinal tracking of individual T-cell clones reveals the expansion of pre-existing T-cell memory in response to SARS-CoV-2 infection.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Spatial correlations constrain cellular lifespan and pattern formation in corneal epithelium homeostasis

    Lior Strinkovsky, Evgeny Havkin ... Yonatan Savir
    Rejuvenation of corneal epithelium in homeostasis is determined by the interplay between corneal cells replicative lifespan and the spatial correlation between cell replication and cell removal.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Thresholds for post-rebound SHIV control after CCR5 gene-edited autologous hematopoietic cell transplantation

    E Fabian Cardozo-Ojeda, Elizabeth R Duke ... Joshua T Schiffer
    Mathematical models reveal the conditions required for long-term HIV remission using autologous transplantation of hematopoietic stem cells.
    1. Computational and Systems Biology
    2. Neuroscience

    Real-time, low-latency closed-loop feedback using markerless posture tracking

    Gary A Kane, Gonçalo Lopes ... Mackenzie W Mathis
    DeepLabCut-Live allows for real-time, ultra-low latency posture tracking of animals.
    1. Computational and Systems Biology
    2. Neuroscience

    Reconsidering the evidence for learning in single cells

    Samuel J Gershman, Petra EM Balbi ... Jeremy Gunawardena
    Single cells are believed to be incapable of complex forms of learning, but reconsideration of historical studies and more recent developments suggest that this orthodoxy must now be reconsidered.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Gene regulation gravitates toward either addition or multiplication when combining the effects of two signals

    Eric M Sanford, Benjamin L Emert ... Arjun Raj
    When two signals increase transcription of the same gene, their combined effect tends to reflect either the sum of the individual increases or the product of the individual fold-changes.
    1. Computational and Systems Biology
    2. Neuroscience

    Diverse and complex muscle spindle afferent firing properties emerge from multiscale muscle mechanics

    Kyle P Blum, Kenneth S Campbell ... Lena H Ting
    Diverse muscle spindle firing, critical for a range of sensorimotor behaviors, is compactly explained by first principles of force development in specialized muscle fibers within the sensors.
    1. Cell Biology
    2. Computational and Systems Biology

    The nucleus serves as the pacemaker for the cell cycle

    Oshri Afanzar, Garrison K Buss ... James E Ferrell Jr
    Just as the sinoatrial node acts as pacemaker for the heart, the nucleus acts as pacemaker for the Xenopus embryonic cell cycle.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Deciphering the combinatorial landscape of immunity

    Antonio Cappuccio, Shane T Jensen ... Elena Zaslavsky
    The immune Synergistic/Antagonistic Interaction Learner (iSAIL) resource has the capacity to generate insight into combinatorial immunity, help guide hypothesis generation and further experimentation relevant to basic research and drug therapeutics.