Browse our latest Computational and Systems Biology articles

Animals work in a world full of surprises, where using energy to position sensors proportional to the location's expected information avoids the pitfalls of positioning them at the information maxima.

Network architecture and physiological features of the cell dictate asymmetric gene regulation between a negative autoregulatory TF gene and its target gene.

Unbiased computational integration of single-cell- and human genetics data shows that susceptibility to obesity is driven by a broad set of neuronal populations across the brain.

CytofRUV is a computational algorithm that effectively enables batch effect reduction in multiple CyTOF batches with an adaptable normalisation method and an R-Shiny application with diagnostics plots.

Cell cycle gating enables a temporal compartmentalization of negative vs positive feedback control processes, leading to differential responses to repetitive interferon stimulations.

Sequencing and counting RNAs from single cells can create a misleading picture of alternative splicing if too many mRNAs are lost in the process.

Analysis and modeling of group behavior of adult zebrafish shows that a specialized social interaction mechanism increases foraging efficiency and equality within groups, under a variety of environmental conditions.

Proper development depends on establishing precise gene expression patterns in spite of the inherent noise in transcription, shadow enhancers buffer this noise by binding distinct input transcription factors.

Arbitration is formalised as the relative precision of predictions afforded by reward and social learning systems and is represented in modality-specific dopaminergic and dopaminoceptive regions, including the midbrain and amygdala.

A new agent-based model enables predicting how coral species richness and functional diversity affect the functioning and resilience of coral reef ecosystems.