Jordan W Squair, Seth Tigchelaar ... Michael A Skinnider
Integrating decades of small-scale experiments with human gene expression data provides a systems-level view of the coordinated molecular processes triggered by spinal cord injury, and their relationship to recovery.
William S DeWitt III, Anajane Smith ... Philip Bradley
An analysis of T cell receptor occurrence patterns that accounts for MHC restriction reveals striking imprints of common viral pathogens and patterns of TCR-HLA sequence covariation in a large human cohort.
Farnoush Farahpour, Mohammadkarim Saeedghalati ... Daniel Hoffmann
In a minimalistic, generic model of competitive communities in which evolution is constrained by life-history trade-offs, stable biodiversity emerges with species adapted to different functional niches.
A deep mutational coupling study demonstrates the ability of sequence coevolution methods to reveal the pattern of amino acid interactions underlying protein function.
Measurement of expression limits of yeast glycolytic proteins reveal the protein burden limit, which is the expression limit of any protein in the cell.
Yeast cell size homeostasis is not controlled by a G1-specific mechanism alone but is likely to be an emergent property resulting from the integration of several mechanisms that coordinate cell and bud growth with division.
QuantEv is a fully automatic and semi-parametric method that allows quantitative analysis of the spatio-temporal distribution of complex molecular trafficking objects at the scale of the whole cell.
t-CyCIF can be used to collect spatially-encoded, multiparametric data from fixed and embedded research or clinical specimens making it possible to probe the organization of tumors and tissues at a single-cell level.
