Browse our latest Computational and Systems Biology articles

Page 90 of 120
    1. Cell Biology
    2. Computational and Systems Biology

    Cell size sensing in animal cells coordinates anabolic growth rates and cell cycle progression to maintain cell size uniformity

    Miriam Bracha Ginzberg, Nancy Chang ... Marc W Kirschner
    Cells employ two strategies, adjusting both their cell cycle lengths and their growth rates in a size-dependent manner, to correct aberrations in cell size.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Metabolic interactions between dynamic bacterial subpopulations

    Adam Z Rosenthal, Yutao Qi ... Michael B Elowitz
    Metabolic division of labor in B. subtilis controls the extracellular environment.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Metabolism: Division of labor in bacteria

    Alma Dal Co, Charlotte Brannon, Martin Ackermann
    The emergence of subpopulations that perform distinct metabolic roles has been observed in populations of genetically identical bacteria.
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    1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    Computational design of thermostabilizing point mutations for G protein-coupled receptors

    Petr Popov, Yao Peng ... Vsevolod Katritch
    A comprehensive approach to prediction of stabilizing mutations in G-protein coupled receptors yields high hit rate and crystal structures of 5HT2C in both active and inactive states.
    1. Cell Biology
    2. Computational and Systems Biology

    Transcriptional profiling reveals extraordinary diversity among skeletal muscle tissues

    Erin E Terry, Xiping Zhang ... Michael E Hughes
    There is no such thing as a representative skeletal muscle tissue, as each member of this family of tissues expresses a specialized mRNA program.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Shearing in flow environment promotes evolution of social behavior in microbial populations

    Gurdip Uppal, Dervis Can Vural
    Shearing in fluid flow induces or enhances budding dispersal in microbial populations, resulting in stronger cooperative behavior.
    1. Computational and Systems Biology
    2. Plant Biology

    Coordination of robust single cell rhythms in the Arabidopsis circadian clock via spatial waves of gene expression

    Peter D Gould, Mirela Domijan ... James CW Locke
    Single cell analysis reveals how period differences between cells and cell-to-cell coupling generates the spatial structure of the plant circadian clock.
    1. Computational and Systems Biology
    2. Epidemiology and Global Health

    The intractable challenge of evaluating cattle vaccination as a control for bovine Tuberculosis

    Andrew James Kerr Conlan, Martin Vordermeier ... James LN Wood
    Natural transmission experiments should be prioritised over risky and expensive field trials, in order to establish the impact of cattle vaccination on the transmission of bovine Tuberculosis.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Computational prediction of CTCF/cohesin-based intra-TAD loops that insulate chromatin contacts and gene expression in mouse liver

    Bryan J Matthews, David J Waxman
    Certain types of 3D chromatin loops are easy to predict from existing or easily obtainable 2D information, which benefits gene expression studies in tissues/cells/organisms without extensive pre-existing 3D information.
    1. Computational and Systems Biology

    The MR-Base platform supports systematic causal inference across the human phenome

    Gibran Hemani, Jie Zheng ... Philip C Haycock
    Compiling public datasets into a single, centralised repository and linking directly to analytical software completely transforms the scale and scope of causal inference across the phenome.