Browse our latest Computational and Systems Biology articles

Activation of the Estrogen Receptor by estra-2-diol results in sustained binding and the previously described cyclical response kinetics are likely an artefact of observing a highly variable process without replicates.

Due to subunit-exchange, CaMKII can store information at diverse time-scales and might play a central role in the memory maintenance.

A new technology for obtaining aged yeast cells helps reveal a striking connection between aging, slow growth, and stress.

A new device for isolating large quantities of old yeast cells expands the experimental boundaries of aging research.

General principles of the limb segment control for terrestrial locomotion have emerged in evolution and highlight the existence of the laws of biological motion that apply to various animal species.

Human gut bacteria alter their metabolism in response to each other's presence, which causes their community dynamics to deviate from predictions that are based on mono-culture data.

Inhibition enhances the spatial specificity of high calcium influx for cooperatively stimulated synapses, suggesting that inhibitory inputs may regulate both synapse-specific and heterosynaptic plasticity to support learning and memory.

The timing and outcome of mammalian cell lineage decisions can be controlled by slow, stochastic events on individual regulatory gene loci.

Tuned protein–protein interaction affinity optimizes the repressive function of the ETS family transcription factor Yan in order to contribute specificity and robustness to cell fate specification in the developing Drosophila eye.

Combining powerful simulation methods uncovers the structural and dynamical changes driving G protein activation in atomic detail, revealing the allosteric network that triggers GDP release and reconciling diverse experimental data.