Browse our latest Developmental Biology articles

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    1. Developmental Biology

    Knockout of cyclin-dependent kinases 8 and 19 leads to depletion of cyclin C and suppresses spermatogenesis and male fertility in mice

    Alexandra V Bruter, Ekaterina A Varlamova ... Victor V Tatarskiy
    Knockout of CDK8/19, but not its inhibition, impairs spermatogenesis by reducing steroid production in Leydig cells.
    1. Developmental Biology

    A systematic review and embryological perspective of pluripotent stem cell-derived autonomic postganglionic neuron differentiation for human disease modeling

    Thomas A Bos, Elizaveta Polyakova ... Monique RM Jongbloed
    Although methods to efficiently generate functional autonomic postganglionic neurons from human pluripotent stem cells largely mirror signaling cues during embryonic development, several in vivo signaling cues remain to be explored in vitro.
    1. Cell Biology
    2. Developmental Biology

    Lens Development: Bringing signaling complexity into focus

    Sarah Y Coomson, Salil A Lachke
    A study in mice reveals key interactions between proteins involved in fibroblast growth factor signaling and how they contribute to distinct stages of eye lens development.
    Version of Record
    Insight
    1. Developmental Biology

    Numb provides a fail-safe mechanism for intestinal stem cell self-renewal in adult Drosophila midgut

    Mengjie Li, Aiguo Tian, Jin Jiang
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Developmental Biology

    3D reconstruction of neuronal allometry and neuromuscular projections in asexual planarians using expansion tiling light sheet microscopy

    Jing Lu, Hao Xu ... Kai Lei
    A high-resolution, high-speed tissue imaging analysis reveals how neural and muscular tissues coordinate during planarian growth and regeneration.
    1. Developmental Biology

    Oviductin sets the species-specificity of the mammalian zona pellucida

    Daniel de la Fuente, Maria Maroto ... Alfonso Gutiérrez-Adán
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Solid
    1. Developmental Biology
    2. Genetics and Genomics

    Deficiency in DNAH12 causes male infertility by impairing DNAH1 and DNALI1 recruitment in humans and mice

    Menglei Yang, Hafiz Muhammad Jafar Hussain ... Baolu Shi
    DNAH12 is essential for sperm flagellar development and male fertility in both humans and mice by interacting with dynein proteins DNAH1 and DNALI1.
    1. Developmental Biology

    Opposing roles for Bmp signalling during the development of electrosensory lateral line organs

    Alexander S Campbell, Martin Minařík ... Clare VH Baker
    In sturgeon, fewer electrosensory organs form after targeting Bmp5 for CRISPR/Cas9-mediated mutagenesis, whereas more form after chemically blocking all Bmp signalling shortly before their primordia emerge, suggesting that Bmp signalling has opposing effects during electrosensory organ development.
    1. Developmental Biology

    Mac/Lac-tosylceramide regulates intestinal homeostasis and secretory cell fate commitment by facilitating Notch signaling

    Kebei Tang, Xuewen Li ... Rongwen Xi
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid