Browse our latest Developmental Biology articles

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    1. Developmental Biology

    Wnt11 acts on dermomyotome cells to guide epaxial myotome morphogenesis

    Ann Kathrin Heilig et al.
    A medaka mutant revealed that Wnt11 promotes formation of uniquely large protrusions from non-myogenic dorsal dermomyotome cells, which guide the epaxial myotome dorsally to achieve the coverage of the neural tube.
    1. Developmental Biology
    2. Physics of Living Systems

    Characterization of convergent thickening, a major convergence force producing morphogenic movement in amphibians

    David R Shook et al.
    Xenopus embryos use tissue surface tension to generate hoop-stress around the blastopore to help close it during gastrulation.
    1. Developmental Biology

    Proteolysis of fibrillin-2 microfibrils is essential for normal skeletal development

    Timothy J Mead et al.
    Proteolytic cleavage of the extracellular matrix glycoprotein fibrillin-2 by the secreted metalloprotease ADAMTS6 influences skeletal development by modulating fibrillin microfibril abundance and GDF5/BMP signaling, illustrating the crucial role of extracellular matrix proteostatic mechanisms in growth factor regulation during morphogenesis.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    AP-2α and AP-2β cooperatively function in the craniofacial surface ectoderm to regulate chromatin and gene expression dynamics during facial development

    Eric Van Otterloo et al.
    In addition to a neural crest cell specific role, AP-2α and AP-2ß cooperatively promote craniofacial development through regulating chromatin and gene expression dynamics in the facial surface ectoderm.
    1. Developmental Biology

    Proper migration of lymphatic endothelial cells requires survival and guidance cues from arterial mural cells

    Di Peng et al.
    Spatio-temporal analysis using live imaging in zebrafish reveals mural cells as a source of pro-lymphangiogenic factors including chemokine and growth factor signalling, necessary for robust lymphatic endothelial cell migration and survival.
    1. Developmental Biology

    Cell-state transitions and collective cell movement generate an endoderm-like region in gastruloids

    Ali Hashmi et al.
    A cellular and biophysical study on embryonic stem cell aggregates reveals that the endoderm can form by a three-step mechanism involving a Wnt/beta-catenin-mediated epiblast fragmentation, tissue flow and cell segregation.
    1. Developmental Biology
    2. Genetics and Genomics

    Precise in vivo functional analysis of DNA variants with base editing using ACEofBASEs target prediction

    Alex Cornean et al.
    An integrated framework for in vivo base edting allows to scalably validate candidate genes and DNA variants.
    1. Cell Biology
    2. Developmental Biology

    Role of YAP in early ectodermal specification and a Huntington's Disease model of human neurulation

    Francesco M Piccolo et al.
    In a model of human neurulation (neuruloids), YAP is deferentially regulated across ecotodermal lineages, where it contributes to their differentiation and structural organization, and is hyper-active upon HD mutation, contributing to an HD-signature phenotype.