EphB4 maintains critical functional properties of the adult cardiac vasculature, namely mechanical resistance and fatty acid transport capability, and thereby prevents dilated cardiomyopathy-like defects.
The cortical collapse factor Efa6 limits axon growth and branching and maintains axonal microtubule bundle integrity by inhibiting microtubule polymerisation at the cell cortex.
Zebrafish develop cardiac lymphatic vessels along coronary arteries and this vasculature supports scar reduction following severe damage to the myocardium.
In vitro reprogramming of human fibroblasts to Sertoli-like cells with immunosuppressive properties provides platforms for basic research and clinical application.
Phenotypic evolution can originate from variations in very precocious developmental events, starting even before fecundation, during the fabrication of the egg in the mother's gonad.
Genetic deletion of one Ptprb allele leads to increased phosphorylation of the TEK receptor, increasing Schlemm's canal area and protecting retinal ganglion cells in a mouse model of glaucoma.
