Browse our latest Developmental Biology articles

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    1. Developmental Biology

    map3k1 is required for spatial restriction of progenitor differentiation in planarians

    Bryanna Isela-Inez Canales, Hunter O King, Peter W Reddien
    map3k1 inhibits progenitor differentiation until suitable positional cues are acquired as a mechanism of pattern formation.
    1. Developmental Biology

    Probing metazoan polyphosphate biology using Drosophila reveals novel and conserved polyP functions

    Sunayana Sarkar, Harsha Sharma ... Manish Jaiswal
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Developmental Biology

    Mouse skeletal muscle satellite cells co-opt the tenogenic gene Scleraxis to instruct regeneration

    Yun Bai, Tyler Harvey ... Chen-Ming Fan
    Muscle stem cells repurpose the tenogenic factor Scx to establish a muscle-specific transcriptional program that sustains stem cell expansion, migration, differentiation, fusion, self-renewal, and survival.
    1. Developmental Biology

    Imp1 acts as a dosage- and stage-dependent temporal rheostat orchestrating radial glial fate transitions and cortical morphogenesis

    Romie Angelo G Azur, Daniel Feliciano ... Tzumin Lee
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Developmental Biology

    Heterochronic transcription factor expression drives cone-dominant retina development in 13-lined ground squirrels

    Kurt Weir, Pin Lyu ... Seth Blackshaw
    Upregulated expression of transcription factors promoting cone identity in late-stage retinal progenitors drives development of the cone-dominant retina of 13-lined ground squirrels.
    1. Developmental Biology

    Dorsoventral-mediated Shh induction is required for axolotl limb regeneration

    Sakiya Yamamoto, Saya Furukawa ... Akira Satoh
    Dorsoventral contact in axolotl limb blastemas induces Shh, showing how positional identities cooperate to drive the regeneration process.
    1. Developmental Biology
    2. Genetics and Genomics

    Single-cell transcriptomics of X-ray irradiated Drosophila wing discs reveals heterogeneity related to cell-cycle status and cell location

    Joyner Cruz, William Y Sun ... Iswar K Hariharan
    Even in a simple epithelial tissue that is exposed uniformly to X-ray irradiation, cells show marked differences in their transcriptional response based on their location and cell-cycle status.
    1. Developmental Biology

    Jam2 Signaling Functions Downstream of Hand2 To Initiate The Formation Of Organ-Specific Vascular Progenitors In Zebrafish

    Martyna Griciunaite, Julius Martinkus ... Saulius Sumanas
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Developmental Biology

    The Drosophila EGF domain protein uninflatable sets the switch between wrapping glia growth and axon wrapping instructed by Notch

    Marie Baldenius, Steffen Kautzmann ... Christian Klämbt
    In Drosophila larva, the Uninflatable protein helps to switch from FGF-receptor triggered glial growth to Notch triggered wrapping of peripheral axons.
    1. Developmental Biology

    Single-nucleus transcriptional and chromatin accessibility analyses of maturing mouse Achilles tendon uncover the molecular landscape of tendon stem/progenitor cells

    Hiroki Tsutsumi, Tomoki Chiba ... Hiroshi Asahara
    Single-cell profiling reveals CD55+CD248+ tendon stem/progenitor cells.