Browse our latest Developmental Biology articles

Dynamic control of intrinsic pluripotent multicellular self-organization to yield robust symmetry breaking patterns that recapitulate morphogenic processes associated with developmental events.

Par3 is polarized in the plane of the vertebrate neural plate, binds and recruits Prickle3 to the apical membrane and promotes the formation of core planar cell polarity complexes.

Ablation of the Cdkn1c cell cycle inhibitor leads to defective muscle stem cell dynamics and myogenic potential, while progressive cytoplasmic to nuclear cellular localization of the Cdkn1c protein regulates growth arrest.

Sox21b-1 regulates simultaneous formation of anterior segments and addition of posterior segments in a spider, which resembles segmentation in long- and short-germ insects, and suggests SoxB regulation of segmentation is an ancestral feature of arthropods.

The discovery of a gene that regulates two segmentation mechanisms in spider embryos is fueling the ongoing debate about the evolution of this crucial developmental process.

Thalidomide and its derivates induce degradation of many C₂H₂ zinc-finger transcription factors, including SALL4, providing insight into a long-standing mystery in modern pharmacology, and starting points for future drug development.

Site-specific DNA methylation analysis at three CG dinucleotides by pyrosequencing provides a reliable measure for epigenetic aging of mice.

A transcription factor called SALL4 could be the missing link between thalidomide and the limb defects caused by the drug.

Analysis of the endogenous function of deeply conserved neuropeptides in sea anemones sheds light on a primitive role of nervous systems in modulating developmental timing.

High levels of nuclear YAP are sufficient to drive squamous cell carincoma formation and frequently also drive progression to spindle cell carcinoma by promoting epithelial-to-mesenchymal transition after tissue damage.