Through the interaction between PCP signaling and N-cadherin, oriented cell division and cell rearrangement are coordinated to establish the appropriate tissue architecture critical for limb skeletal morphogenesis.
Genome-wide RNA-seq analysis of single cells of the developing mouse endolymphatic sac reveals its molecular-cellular architecture and a model for salt and fluid absorption required for acquisition of normal inner ear structure and function.
The transcription factor GATA6 selects the embryonic vessels that will be reorganized into the major thoracic arteries by promoting local differentiation of vascular smooth muscle cells.
Colleen E Hannon, Shelby A Blythe, Eric F Wieschaus
Interplay between protein concentration, DNA binding and remodeling of the chromatin landscape in early embryogenesis determines how a single transcription factor can specify multiple distinct gene expression states.
M Joaquina Delás, Leah R Sabin ... Gregory J Hannon
A comprehensive analysis of long noncoding RNAs in the hematopoietic system reveals their dynamic regulation and a loss-of-function screen identifies some required for leukemia progression and involved in normal myeloid differentiation.
Regional differences in activator and inhibitor signals alter hair cycle pace across mouse skin and produce unique fur renewal 'landscapes', with fastest renewal on the ventrum and slowest renewal on the ear pinnae.
Sylvie Remaud, Fernando C Ortiz ... Barbara Demeneix
Production of remyelinating subventricular zone oligodendrocyte progenitors is stimulated by transient abrogation of thyroid hormone signalling in the adult neural stem cell niche.
