Browse our latest Developmental Biology articles

A high-throughput functional validation system for large numbers of candidate disease genes enables in vivo functional testing of specific gene variants.

Studies in zebrafish and mouse implicate the PDGF signaling pathway in the communication between the endoderm and the myocardium that drives medial myocardial movement and thereby initiates cardiac morphogenesis.

A method for measuring p300 chromatin occupancy in specific lineages of mouse tissues was used to map endothelial enhancers and to identify previously unrecognized angiogenesis-related sequence motifs.

Genetic modulation in patterns of tissue conflict play a major role in the development and evolution of shape diversity.

Experiments in zebrafish reveal a new role for a critical hypothalamic transcription factor, orthopedia, in controlling developmental neuropeptide balance in a discrete oxytocin-producing neuronal circuit whose disrupted development affects social behavior.

A novel molecular strategy to block transcription factor activity using small molecule interference of multiple protein-protein interactions is reported.

A small molecule called Sm4 can disrupt interactions involving a transcription factor called Sox18, while having little impact on other members of the SoxF family.

The formation of new neurons in the adult dentate gyrus causes a proportion of cortical neurons to transfer their existing connections to the newborn cells.

Building on previous work (Haldipur et al., 2014), we show that many key mechanisms controlling cerebellar development are likely conserved between mouse and human, and validate our mouse model of Dandy-Walker malformation.

A competition for RNA drives the localized assembly of RNA granules in the C. elegans embryo.