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Although complete mouse in vitro spermatogenesis can be achieved, failure of adult Leydig cell development, with accumulation of progesterone and estradiol, androstenedione deficiency, deregulation of steroidogenic, and steroid target gene expression, were highlighted in organotypic cultures, even with hCG.

Phosphorylation of the pseudokinase Ulk4 by Stk36 promotes primary ciliary tip localization of both proteins to facilitate the phosphorylation and activation of Gli in response to Sonic hedgehog.

Dynamic compartmentalization of the pro-invasive transcription factor NHR-67 reveals a role for members of the Groucho/TCF repressive complex in maintaining non-invasive cell fate in C. elegans.

Imaging experiments reveal the complex and dynamic nature of the transcriptional hubs associated with Notch signaling.

Cylicin 1 and Cylicin 2 are essential components of the sperm perinuclear theca and their loss results in impaired spermiogenesis and thus in infertility in mice and men.

On different bacterial diets, which also serve as different environments for Caenorhabditis elegans, specific sensory neurons and insulin-like peptides integrate food-derived signals to modulate oocyte biology, and hence reproduction.

The accumulation of ferroptotic stress during tooth development has a critical effect on its morphogenesis.

Combined single nucleus RNAseq and ATACseq enabled the first molecular resolution of all hindbrain rhombomeres, the derivation of a unique gene regulatory network for each rhombomere, and the identification of gene expression changes as rhombomeres form from early progenitor pools.

Single-cell transcriptome analyses during cortical brain development in ferrets and its comparison with public human datasets reveal that there are common progenitors and lineages among gyrencephalic mammalian brain development.