Browse our latest Developmental Biology articles

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    1. Developmental Biology

    Single-cell RNA sequencing unravels the transcriptional network underlying zebrafish retina regeneration

    Laura Celotto, Fabian Rost ... Michael Brand
    Single-cell transcriptome analysis of the regenerating retina in adult zebrafish reveals molecular control steps during Müller glia stem cell activation, progressive differentiation, and neural regeneration.
    1. Developmental Biology

    The myocardium utilizes a platelet-derived growth factor receptor alpha (Pdgfra)–phosphoinositide 3-kinase (PI3K) signaling cascade to steer toward the midline during zebrafish heart tube formation

    Rabina Shrestha, Tess McCann ... Joshua Bloomekatz
    Research on heart tube assembly using zebrafish reveals a pivotal role for intrinsic Pdgfra–PI3K signaling in steering the movement of the myocardium and polarizing myocardial cell protrusions.
    1. Developmental Biology

    Conditional blastocyst complementation of a defective Foxa2 lineage efficiently promotes the generation of the whole lung

    Akihiro Miura, Hemanta Sarmah ... Munemasa Mori
    The Foxa2 lineage-based organ generative strategy allows us to establish a unique paradigm for the simultaneous generation of functional whole lungs and thymus, which can be applied to future transplantation therapy.
    1. Developmental Biology
    2. Plant Biology

    The Arabidopsis SHORTROOT network coordinates shoot apical meristem development with auxin-dependent lateral organ initiation

    Elmehdi Bahafid, Imke Bradtmöller ... Rüdiger GW Simon
    Mutant and gene expression analyses shows that phytohormones and mobile transcription factors interact to coordinate organ formation with stem cell maintenance in the plant shoot meristem.
    1. Developmental Biology
    2. Neuroscience

    Transcriptional control of motor pool formation and motor circuit connectivity by the LIM-HD protein Isl2

    Yunjeong Lee, In Seo Yeo ... Mi-Ryoung Song
    Isl2 orchestrates specific hindlimb motor pool arrangement, guaranteeing accurate motor control and sensorimotor circuit functionality.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Asymmetric inheritance of centrosomes maintains stem cell properties in human neural progenitor cells

    Lars N Royall, Diana Machado ... Annina Denoth-Lippuner
    Genetic birthdating in forebrain organoids shows asymmetric inheritance of centrosomes in human neural progenitor cells, required for proper human neurogenesis.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    Modulation of protein-DNA binding reveals mechanisms of spatiotemporal gene control in early Drosophila embryos

    Sahla Syed, Yifei Duan, Bomyi Lim
    TF-DNA binding regulates spatial and temporal gene expression and drives robust pattern formation by modulating transcriptional kinetics via cooperative interactions among weak TF binding sites and tuning bursting rates by reducing the time spent in the ON state.
    1. Developmental Biology

    Single-cell profiling coupled with lineage analysis reveals vagal and sacral neural crest contributions to the developing enteric nervous system

    Jessica Jacobs-Li, Weiyi Tang ... Marianne E Bronner
    Single-cell transcriptome analysis of sacral compared with vagal neural crest-derived cells in the developing chick enteric nervous system reveals both similarities and differences between these two cell populations.
    1. Developmental Biology
    2. Neuroscience

    Using multi-modal neuroimaging to characterise social brain specialisation in infants

    Maheen Siddiqui, Paola Pinti ... Emily JH Jones
    The coupling between neural oscillatory activity, haemodynamics, and metabolism is localised to the temporo-parietal region in response to social stimuli, providing evidence of the importance of investigating the energetic basis of brain functional specialisation.
    1. Developmental Biology

    A human mitofusin 2 mutation can cause mitophagic cardiomyopathy

    Antonietta Franco, Jiajia Li ... Gerald W Dorn
    A rare human mitofusin (MFN) 2 mutation that uniquely impaired Parkin-mediated mitophagy evoked developmental heart disease and increased myocardial sensitivity to doxorubicin in mice, differentiating it from mitophagy-competent MFN2 mutations that cause neuropathy and implicating mitophagy in clinical cardiomyopathy.