Although many Apical Ectodermal Ridge signaling components are found in the axolotl limb epidermis, responsiveness to canonical Wnt signaling has shifted to the limb mesenchyme where it regulates mesenchymal Fgf8 expression.
Normal adipogenesis requires de novo DNA methyltransferase 3A (DNMT3A) for proper differentiation and suppression of an age-associated pathogenic inflammatory program.
Computational modelling and experimental manipulation show that Notch signalling regulates collective cell migration by allocating distinct migratory identities through the control of cell cycle progression.
Maja Solman, Sasja Blokzijl-Franke ... Jeroen den Hertog
The transcriptomes of hematopoietic stem and progenitor cells of human juvenile myelomonocytic leukemia patients and a zebrafish model for Noonan syndrome reveal a common inflammatory response, which may have a causal role in associated myeloproliferative neoplasm.
Scott R Allen, Rebeccah K Stewart ... Donald T Fox
A tissue-wide fluoresence-based screen reveals that not all tissues in an organism (Drosophila) reinforce a hierarchy of codon usage to the same extent, a finding which impacts tissue-specific protein expression and function.
David J Turner, Alexander Saveliev ... Martin Turner
A genetic screening approach identifies RNA binding proteins that enhance or inhibit the accumulation of CD138+ plasma cells in vitro, and chimeric mouse models demonstrate that YTHDF2 promotes the accumulation of antibody secreting cells in vivo.
Highly reproducible and efficient human primordial germ cell differentiation was achieved through geometric confinement, which enabled quantitative dissection of the cell signaling driving this differentiation, revealing a major role of Wnt signaling is indirect by inducing Nodal signaling.
Ann Kathrin Heilig, Ryohei Nakamura ... Toru Kawanishi
A medaka mutant revealed that Wnt11 promotes formation of uniquely large protrusions from non-myogenic dorsal dermomyotome cells, which guide the epaxial myotome dorsally to achieve the coverage of the neural tube.
