The neonatally maturing pituitary harbors an activated stem cell compartment and shows prominent regenerative capacity, as revealed by single-cell transcriptomic profiling and in vitro (organoid) and in vivo (mouse) exploration.
Yap interacts with Rif1, a major DNA replication timing factor, and functions as a brake to control the DNA replication program in Xenopus early embryos and post-embryonic stem cells.
Single cell RNA-sequencing of distinct regions of the human placenta identifies a smooth chorion-specific cytotrophoblast population responsible for unique functions of the smooth chorion, including acting as a barrier and restricting invasion.
Camila Cupello, Tatsuya Hirasawa ... Paulo M Brito
The primitive state of vertebrate lungs is unpaired, evolving to be truly paired in the lineage towards the tetrapods, increasing the pulmonary efficiency during the water-to-land transition.
Daniela Ávila-González, Wendy Portillo ... Néstor F Díaz
Interaction of human embryonic stem cells (hESC) with human amniotic epithelial cells (hAEC) confers hESC a pluripotent potential that resembles the anteriorized epiblast, which is predisposed to form the neural ectoderm.
Lewis Macdonald, Gillian C Taylor ... Andrew J Wood
Auxin-inducible degradation of CRISPR-tagged endogenous proteins in mice reveals cell-type-specific dependence on the mitotic chromosome condensation proteins.
Carrie E Leonard, Jolie Quiros ... Lisa A Taneyhill
Trigeminal nerve deficits observed in familial dysautonomia, which arises from mutations in ELP1, are due to loss of neural crest-derived TrkA nociceptors, while placode-derived TrkB and TrkC neurons are spared.
