Carriage of MDR S. Typhi H58 sublineages that also cause acute disease provides understanding of the transmission dynamics of typhoid fever and maintenance of local pathogen populations in Kenya children.
Morgan P Kain, Eloise B Skinner ... Erin A Mordecai
The role host and vector species play in pathogen transmission cycles is best quantified by integrating species' physiological and ecological competence.
Genetic integration of human protein abundance variation and COVID-19 susceptibility identifies proteins with potential causal roles in antiviral responses, coagulation, cytokine activation, and direct receptor interactions with SARS-CoV-2.
Lawrence Lubyayi, Harriet Mpairwe ... Alison M Elliott
In a Ugandan birth cohort, early childhood infection-exposure, notably to malaria, helminths, and diarrhoea, is associated with lower prevalence of atopy and allergy-related diseases in later childhood.
Hannah R Meredith, John R Giles ... Amy Wesolowski
Mobile phone data reveal aspects of human mobility patterns in Sub-Saharan Africa missed by standard spatial models however, model estimates can be improved by accounting for trip urbanicity and region.
Corbin SC Johnson, Carol A Shively ... Noah Snyder-Mackler
Modern human diet patterns alter primate behavior and monocyte gene expression leading to monocyte polarization–experimental evidence of the evolutionary mismatch hypothesis.
The physician involving the woman as much as she wants in her health care is significantly associated with up-to-date dual cervical and colorectal cancer screening compared to being up to date in only cervical cancer screening.
Steven J Clipman, Shruti H Mehta ... Sunil S Solomon
Beyond well-recognized individual-level risk factors, HIV and hepatitis C transmission among people who inject drugs are further impacted by social and spatial network composition, and spaces in particular may represent efficient means for disseminating interventions that diffuse through the network.
Gerry Tonkin-Hill, Inigo Martincorena ... Wellcome Sanger Institute COVID-19 Surveillance Team
Characterisation of within-host diversity of SARS-CoV-2 provides insights into the mutational and selective mechanisms driving its evolution and has important implications for using within-host variation to inform transmission inference efforts.
