A new mathematical model that can be applied to both single-cell and bulk DNA sequencing data sheds light on the processes governing population dynamics in stem cells.
Achieving autotrophy in E. coli by introducing a small number of genetic changes crosses a milestone in engineering major metabolic transitions and paves a way for sustainable bio-production from CO2.
Germline mutation rates in mice are shaped by two mutator alleles that interact epistatically, showing that DNA repair defects that map to different loci can have snowballing effects.
Exploring tissue-specific regulation of gene expression with human-chimpanzee hybrid cells helps us understand how life evolves and what makes us human.
Paul Knabl, Alexandra Schauer ... Grigory Genikhovich
ChIP-seq analysis reveals BMP signaling targets in a cnidarian and identifies ZSWIM4-6 as a dampener of the pSMAD1/5 gradient and a potential conveyor of the BMP-mediated gene repression.