Browse our latest Genetics and Genomics articles

Page 103 of 143
    1. Genetics and Genomics
    2. Neuroscience

    A genetic, genomic, and computational resource for exploring neural circuit function

    Fred P Davis, Aljoscha Nern ... Gilbert L Henry
    Transcriptomes of cells in the Drosophila visual system combined with anatomy and other information reveal new functional insight into the visual circuit.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Rapid sex-specific adaptation to high temperature in Drosophila

    Sheng-Kai Hsu, Ana Marija Jakšić ... Christian Schlötterer
    Within 100 generations after an environmental shift in an evolution experiment, rapid sex-specific adaptation occurred, which is potentially facilitated by selection on standing variation in sex-specific genetic architecture.
    1. Genetics and Genomics

    Loss of centromere function drives karyotype evolution in closely related Malassezia species

    Sundar Ram Sankaranarayanan, Giuseppe Ianiri ... Kaustuv Sanyal
    The centromeres in Malassezia species, by breakage or inactivation, facilitate genome rearrangements that can result in varying karyotypes and contribute to the evolution of these species.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Pan-mammalian analysis of molecular constraints underlying extended lifespan

    Amanda Kowalczyk, Raghavendran Partha ... Maria Chikina
    Cancer control, DNA repair, and immunity are key functionalities underlying the evolution of extended lifespan in mammals.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    CNApp, a tool for the quantification of copy number alterations and integrative analysis revealing clinical implications

    Sebastià Franch-Expósito, Laia Bassaganyas ... Jordi Camps
    CNApp is a novel and unique web-based software that enables the performance of comprehensive and integrative analysis of genomic copy number alterations to uncover new associations with patient-oriented relevance.
    1. Developmental Biology
    2. Genetics and Genomics

    celsr1a is essential for tissue homeostasis and onset of aging phenotypes in the zebrafish

    Chunmei Li, Carrie Barton ... Matthew P Harris
    The use of forward genetic screens in zebrafish identifies a new model of vertebrate aging, defining the regulating of the onset of aging phenotypes through maintenance of progenitor cell populations.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Deep learning models predict regulatory variants in pancreatic islets and refine type 2 diabetes association signals

    Agata Wesolowska-Andersen, Grace Zhuo Yu ... Mark I McCarthy
    Combination of deep learning models trained on tissue-specific genomic data and fine-mapping approaches supports efforts to identify causal variants and mechanisms at GWAS loci.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Attacks on genetic privacy via uploads to genealogical databases

    Michael D Edge, Graham Coop
    Direct-to-consumer genetic genealogy services that allow users to upload their own datasets are vulnerable to attacks on genetic privacy that exploit the structure of genetic variation.
    1. Genetics and Genomics
    2. Stem Cells and Regenerative Medicine

    Multiplex CRISPR/Cas screen in regenerating haploid limbs of chimeric Axolotls

    Lucas D Sanor, Grant Parker Flowers, Craig M Crews
    A novel CRISPR-based genetic screen of candidate regeneration genes in haploid axolotl limbs reveals two genes required for proper regeneration.
    1. Developmental Biology
    2. Genetics and Genomics

    GLI transcriptional repression regulates tissue-specific enhancer activity in response to Hedgehog signaling

    Rachel K Lex, Zhicheng Ji ... Steven A Vokes
    GLI3 represses Hedgehog target gene expression by regulating histone modifications at a subset of tissue-specific GLI-bound enhancers.