Browse our latest Genetics and Genomics articles

Genome-wide association studies on a diallel yeast panel revealed the relevance of low-frequency variants on the phenotypic diversity and consequently on the missing heritability at a population-scale.

Rare, evolutionarily recent variants have larger effect sizes and are more likely to decrease fitness, providing evidence that quantitative traits in yeast have evolved under purifying selection.

Rare genetic variants in yeast explain a large amount of phenotypic variation in a complex trait like growth.

OCT4 and SOX2 display partially independent activity to regulate chromatin accessibility, and highly dynamic activity of OCT4 is required throughout the cell cycle to maintain pluripotency enhancer accessibility.

Reconstruction of great auk population dynamics suggests that hunting pressure alone could have been responsible for their extinction, demonstrating that even abundant, widespread species can be vulnerable to intense exploitation.

Tumor immunogenicity is quantified with a novel method, and the resulting tumor immunogenicity score is an effective tumor-inherent biomarker for prediction of response to immune checkpoint inhibitors.

The X-linked loci Firre and Dxz4 are involved in autosomal gene regulation rather than XCI biology.

Using a suite of CRISPR technologies, unique chemical tools, and carefully designed biochemical and cell biological assays, we define the mechanism of action of Retro-2, an inhibitor of retrograde toxins.

Diverse morphologies of Drosophila T4/T5 neuronal subtypes are defined by the modular assembly of transcriptional programs for distinct wiring features.

Optimization of homology donor DNA production and integration schemes facilitates homologous recombination in vivo and in cell culture in Drosophila melanogaster..