Browse our latest Genetics and Genomics articles

Page 107 of 143
    1. Genetics and Genomics

    Obesity-linked suppression of membrane-bound O-acyltransferase 7 (MBOAT7) drives non-alcoholic fatty liver disease

    Robert N Helsley, Venkateshwari Varadharajan ... J Mark Brown
    Loss of function of membrane-bound O-acyltransferase 7 (MBOAT7), but not transmembrane channel-like 4 (TMC4), promotes hepatic steatosis.
    1. Genetics and Genomics

    One-step efficient generation of dual-function conditional knockout and geno-tagging alleles in zebrafish

    Wenyuan Li, Yage Zhang ... Bo Zhang
    Conditional gene knockout in combination with fluorescent labeling of different alleles can be achieved with high efficiency in zebrafish through NHEJ-mediated targeted insertion using a CRISPR/Cas system.
    1. Genetics and Genomics
    2. Immunology and Inflammation

    SCGN deficiency results in colitis susceptibility

    Luis F Sifuentes-Dominguez, Haiying Li ... Ezra Burstein
    A novel mutation in SCGN is associated with risk for inflammatory bowel disease and implicates the intestinal neuroendocrine compartment in the pathogenesis of this disorder.
    1. Developmental Biology
    2. Genetics and Genomics

    The GATOR complex regulates an essential response to meiotic double-stranded breaks in Drosophila

    Youheng Wei, Lucia Bettedi ... Mary A Lilly
    The GATOR complex regulates TORC1 activity during meiosis.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Philosophy of Biology: The meanings of 'function' in biology and the problematic case of de novo gene emergence

    Diane Marie Keeling, Patricia Garza ... Anne-Ruxandra Carvunis
    A lexicon to help scientists and philosophers discuss the meaning of function in molecular biology more clearly is proposed.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Comment on 'Single nucleus sequencing reveals evidence of inter-nucleus recombination in arbuscular mycorrhizal fungi'

    Benjamin Auxier, Anna Bazzicalupo
    We are writing to comment on the article by Chen et al. (2018) about inter-nucleus recombination in arbuscular mycorrhizal fungi.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Herpes simplex viral nucleoprotein creates a competitive transcriptional environment facilitating robust viral transcription and host shut off

    Sarah E Dremel, Neal A DeLuca
    Herpes simplex ICP4 preferentially binds to and delineates the viral genome, ultimately resulting in robust viral transcription at the expense of the host.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Cis-regulatory basis of sister cell type divergence in the vertebrate retina

    Daniel P Murphy, Andrew EO Hughes ... Joseph C Corbo
    While photoreceptor and bipolar cells exhibit very similar cis-regulatory grammars, subtle differences in homeodomain motif enrichment represent a key distinction driving the divergence in their transcriptomes.
    1. Cell Biology
    2. Genetics and Genomics

    The Mars1 kinase confers photoprotection through signaling in the chloroplast unfolded protein response

    Karina Perlaza, Hannah Toutkoushian ... Silvia Ramundo
    A genetic screen in a unicellular photosynthetic organism uncovers the first essential signaling component in the chloroplast unfolded protein response that relays information from the chloroplast to the nuclear compartment.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Mating Behavior: When structure meets function

    Sarah A Signor
    A new study upturns the long-held belief that in fruit flies, the yellow gene determines sex-specific behaviors by acting in the brain.
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