Browse our latest Genetics and Genomics articles

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    1. Evolutionary Biology
    2. Genetics and Genomics

    Reproduction: How flies turn food into progeny

    Thomas Flatt
    Sex-optimal diets have different effects on gene expression in female and male flies.
    Version of Record
    Insight
    1. Evolutionary Biology
    2. Genetics and Genomics

    A de novo evolved gene in the house mouse regulates female pregnancy cycles

    Chen Xie, Cemalettin Bekpen ... Diethard Tautz
    A female specifically expressed new protein-coding gene that has emerged out of non-coding sequences without detectable signatures of adaptive evolution affects female pregnancy cycles.
    1. Genetics and Genomics

    Large, three-generation human families reveal post-zygotic mosaicism and variability in germline mutation accumulation

    Thomas A Sasani, Brent S Pedersen ... Aaron R Quinlan
    Rates of germline mutation accumulation are highly variable across families of similar genetic ancestry, and post-zygotic mosaicism is a substantial source of de novo mutations.
    1. Developmental Biology
    2. Genetics and Genomics

    Extensive intraspecies cryptic variation in an ancient embryonic gene regulatory network

    Yamila N Torres Cleuren, Chee Kiang Ewe ... Joel H Rothman
    Quantitative genetic analyses reveal remarkably broad genetic variation underlies the requirement for two critical regulatory inputs into a core embryonic gene regulatory network within one animal species.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    The Photorhabdus asymbiotica virulence cassettes deliver protein effectors directly into target eukaryotic cells

    Isabella Vlisidou, Alexia Hapeshi ... Nicholas R Waterfield
    The insect pathogenic bacterium Photorhabdus has evolved astonishing nano-scale analogues of hypodermic syringes that it uses to inject toxins into host cells.
    1. Genetics and Genomics
    2. Neuroscience

    Learning is enhanced by tailoring instruction to individual genetic differences

    David G Mets, Michael S Brainard
    Tailoring instructive experience to individual genetic biases improves vocal learning outcomes across genetic backgrounds in the Bengalese finch.
    1. Genetics and Genomics
    2. Plant Biology

    Epigenetic silencing of a multifunctional plant stress regulator

    Mark Zander, Björn C Willige ... Joseph R Ecker
    Interplay between histone demethylation and chromatin remodeling shapes the chromatin environment of the essential stress regulator ETHYLENE-INSENSITIVE2.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    A genetic selection reveals functional metastable structures embedded in a toxin-encoding mRNA

    Sara Masachis, Nicolas J Tourasse ... Fabien Darfeuille
    A genetic selection of toxicity suppressors coupled to high-throughput sequencing has captured metastable RNA structures that co-transcriptionally inhibit the translation of a bacterial toxin.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Host-Pathogen Interactions: What makes the hepatitis C virus evolve?

    Thomas R O'Brien, Rune Hartmann, Ludmila Prokunina-Olsson
    Polymorphisms in the IFNL4 gene that affect both the form and the activity of the coded protein are associated with changes in the hepatitis C virus.
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    Insight
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Interferon lambda 4 impacts the genetic diversity of hepatitis C virus

    M Azim Ansari, Elihu Aranday-Cortes ... Vincent Pedergnana
    Interferon lambda 4, a protein part of the innate immune response, drives major amino acids selection in patients chronically infected with hepatitis C virus.