Browse our latest Genetics and Genomics articles

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    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Dynamics of genomic innovation in the unicellular ancestry of animals

    Xavier Grau-Bové, Guifré Torruella ... Iñaki Ruiz-Trillo
    The foundations of genomic complexity in multicellular animals have deep roots in their unicellular prehistory, both in terms of innovations in gene content, as well as the evolutionary dynamics of genome architecture.
    1. Stem Cells and Regenerative Medicine
    2. Genetics and Genomics

    Mobilization of LINE-1 retrotransposons is restricted by Tex19.1 in mouse embryonic stem cells

    Marie MacLennan, Marta García-Cañadas ... Ian R Adams
    Post-translational regulation of retrotransposons plays a key role in preventing retrotransposon mobilization in the epigenetically dynamic mouse germline.
    1. Developmental Biology
    2. Genetics and Genomics

    Mapping the mouse Allelome reveals tissue-specific regulation of allelic expression

    Daniel Andergassen, Christoph P Dotter ... Quanah J Hudson
    Allele-specific expression due to genetic differences, X-chromosome inactivation or genomic imprinting, varies dynamically throughout development, and may be explained by allele-specific differences in stability or the actions of tissue-specific enhancers.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    CRISPR-mediated genetic interaction profiling identifies RNA binding proteins controlling metazoan fitness

    Adam D Norris, Xicotencatl Gracida, John A Calarco
    Synthetic genetic analysis in C. elegans identifies pairs of RNA binding protein genes that play a critical role in organism health and development.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Extensive horizontal gene transfer in cheese-associated bacteria

    Kevin S Bonham, Benjamin E Wolfe, Rachel J Dutton
    The identification of horizontally transferred genes, and commonly transferred functions, can provide a window into the selective forces acting on species within an ecosystem.
    1. Genetics and Genomics

    Repeated losses of PRDM9-directed recombination despite the conservation of PRDM9 across vertebrates

    Zachary Baker, Molly Schumer ... Molly Przeworski
    PRDM9 is widely conserved across vertebrates yet has been lost numerous times, as has its role in directing meiotic recombination.
    1. Genetics and Genomics

    Meiotic Recombination: Birth and death of a protein

    Julie Clément, Bernard de Massy
    The ways in which recombination sites are determined during meiosis are becoming clearer following a phylogenomic analysis for 225 different species.
    Version of Record
    Insight
    1. Genetics and Genomics

    Minimal-assumption inference from population-genomic data

    Daniel B Weissman, Oskar Hallatschek
    The coalescent history of a population can be learned just from the present genomic diversity, without having detailed prior knowledge of the pattern of recombination or the forces driving coalescence.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    A novel twelve class fluctuation test reveals higher than expected mutation rates for influenza A viruses

    Matthew D Pauly, Megan C Procario, Adam S Lauring
    A new assay for specific mutational classes provides preciseestimates of the mutation rates and mutational bias for influenza A viruses.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Virus Evolution: A new twist in measuring mutation rates

    Bartram L Smith, Claus O Wilke
    The influenza virus mutates faster than we previously thought.
    Version of Record
    Insight