Browse our latest Genetics and Genomics articles

Page 128 of 143
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Host-selected mutations converging on a global regulator drive an adaptive leap towards symbiosis in bacteria

    M Sabrina Pankey, Randi L Foxall ... Cheryl A Whistler
    Selective forces imposed by the squid animal host drive rapid adaptation of non-native Vibrio fischeri bacteria through convergent mutations of large effect, unmasking preexisting coordinated regulation of symbiosis.
    1. Genetics and Genomics

    Palaeogenomes of Eurasian straight-tusked elephants challenge the current view of elephant evolution

    Matthias Meyer, Eleftheria Palkopoulou ... Michael Hofreiter
    DNA sequences from the Middle Pleistocene reveal that the extinct Eurasian straight-tusked elephants were closely related to today's African forest elephants (Loxodonta cyclotis) in Africa.
    1. Genetics and Genomics

    Introduction of a male-harming mitochondrial haplotype via ‘Trojan Females’ achieves population suppression in fruit flies

    Jonci Nikolai Wolff, Neil J Gemmell ... Damian K Dowling
    Mitochondrial genomes harbor male-fertility-reducing mutations that can be harnessed to control population viability as a novel approach to control economic and environmental pests.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Histone gene replacement reveals a post-transcriptional role for H3K36 in maintaining metazoan transcriptome fidelity

    Michael P Meers, Telmo Henriques ... A Gregory Matera
    Post-translational modification of histone H3K36 is not required to suppress cryptic transcription initiation or to include alternative exons in Drosophila; instead it promotes expression of active genes by stimulating polyadenylation.
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Evolution of substrate specificity in a retained enzyme driven by gene loss

    Ana Lilia Juárez-Vázquez, Janaka N Edirisinghe ... Francisco Barona-Gómez
    An integrated biochemical and evolutionary analysis shows how enzyme specificity evolves after gene loss during genome decay, implicating relaxation of purifying selection as a driving force for functional divergence.
    1. Genetics and Genomics
    2. Neuroscience

    Variation in olfactory neuron repertoires is genetically controlled and environmentally modulated

    Ximena Ibarra-Soria, Thiago S Nakahara ... Darren W Logan
    The neuronal composition of a mouse’s nose is individually unique due to a combination of olfactory experience and genetic variation local to olfactory receptor genes.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    A team of heterochromatin factors collaborates with small RNA pathways to combat repetitive elements and germline stress

    Alicia N McMurchy, Przemyslaw Stempor ... Julie Ahringer
    Genome-wide profiling and functional analyses reveal a network of heterochromatin and small RNA factors that silences repetitive elements and prevents genotoxic stress to ensure fertility.
    1. Genetics and Genomics

    Gene regulatory network plasticity predates a switch in function of a conserved transcription regulator

    Isabel Nocedal, Eugenio Mancera, Alexander D Johnson
    Rapid evolutionary rewiring of the meiosis transcription network facilitated a switch in the function of a master regulator from regulating meiosis to regulating biofilm formation.
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Genome mining unearths a hybrid nonribosomal peptide synthetase-like-pteridine synthase biosynthetic gene cluster

    Hyun Bong Park, Corey E Perez ... Jason M Crawford
    A new type of hybrid nonribosomal peptide synthetase (NRPS)-like-pteridine synthase biosynthetic pathway has been illuminated via genome mining.
    1. Genetics and Genomics

    Point of View: How should the applications of genome editing be assessed and regulated?

    Robin Fears, Volker ter Meulen
    An EASAC working group on genome editing recommends that regulators should focus on specific applications of these new techniques rather than attempting to regulate genome editing itself as a new technology.