Browse our latest Genetics and Genomics articles

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    1. Genetics and Genomics

    Expression of SREBP-1c Requires SREBP-2-mediated Generation of a Sterol Ligand for LXR in Livers of Mice

    Shunxing Rong, Víctor A Cortés ... Jay D Horton
    SREBP-2 directly regulates genes involved in cholesterol homeostasis and indirectly regulates fatty acid synthesis through the production of a ligand responsible for the activation of LXR and SREBP-1c.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    A phylogenetic transform enhances analysis of compositional microbiota data

    Justin D Silverman, Alex D Washburne ... Lawrence A David
    The PhILR transform uses an evolutionary model to overcome statistical challenges associated with microbiota surveys.
    1. Genetics and Genomics
    2. Neuroscience

    Layer-specific chromatin accessibility landscapes reveal regulatory networks in adult mouse visual cortex

    Lucas T Gray, Zizhen Yao ... Bosiljka Tasic
    ATAC-seq, transcriptomics, and transcription factor motif searches collaborate to build a network that regulates gene expression in different cortical layers.
    1. Genetics and Genomics

    Codon optimization underpins generalist parasitism in fungi

    Thomas Badet, Remi Peyraud ... Sylvain Raffaele
    Codon optimization through biased synonymous substitutions is a characteristic feature of the genomes of generalist fungal parasites and is associated with the colonization of multiple hosts.
    1. Ecology
    2. Genetics and Genomics

    Novel adverse outcome pathways revealed by chemical genetics in a developing marine fish

    Elin Sørhus, John P Incardona ... Sissel Jentoft
    Global gene expression analysis unravels the underlying mechanisms for distinct crude oil induced defects in Atlantic haddock eggs and larvae.
    1. Genetics and Genomics

    Comparative genetic screens in human cells reveal new regulatory mechanisms in WNT signaling

    Andres M Lebensohn, Ramin Dubey ... Rajat Rohatgi
    A systematic genetic analysis comprising seven genome-wide screens in haploid human cells uncovered new regulatory mechanisms at most levels in the WNT signaling pathway.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Characterisation of the opposing effects of G6PD deficiency on cerebral malaria and severe malarial anaemia

    Geraldine M Clarke, Kirk Rockett ... MalariaGEN Consortium
    Increasing levels of glucose-6-phosphate dehydrogenase deficiency are associated with decreasing risk of cerebral malaria, but with increased risk of severe malarial anaemia.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Structure of the germline genome of Tetrahymena thermophila and relationship to the massively rearranged somatic genome

    Eileen P Hamilton, Aurélie Kapusta ... Robert S Coyne
    The model organism Tetrahymena thermopile carries two nuclei with distinct genomes: an unrearranged germline genome with five chromosomes, and a somatic genome reduced in size by a third and with 181 chromosomes.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Population scale mapping of transposable element diversity reveals links to gene regulation and epigenomic variation

    Tim Stuart, Steven R Eichten ... Ryan Lister
    Fine mapping of transposable element presence/absence variation amongst 216 Arabidopsis strains uncovers widespread novel genetic diversity that underlies differences in transcription and DNA methylation patterns.