Genome-wide analysis of DNA methylation and accessible chromatin shows that retinal rods and cones have distinct epigenomic features that reflect differences in their development and function.
David George Ashbrook, Beatrice Gini, Reinmar Hager
A cross-fostered population of mice reveals loci on offspring chromosomes 5 and 7 that modify the behaviour of their mothers, along with evidence of coadaptation between offspring and parental traits.
The protozoan parasite Trypanosoma brucei gambiense has undergone recent clonal evolution that reveals the theoretically predicted Meselson effect at a genome-wide level.
Lauren M Dembeck, Katalin Böröczky ... Trudy F C Mackay
Genome wide association analyses in a wild-derived Drosophila melanogaster population uncover extensive variation in cuticular hydrocarbon composition, which may present a target for natural selection and adaptive evolution.
William G Pembroke, Arran Babbs ... Peter L Oliver
RNA sequencing reveals the finer details of circadian variation in the mammalian master pacemaker over 24 hours, which suggests that transcriptional timing influences clock resetting mechanisms.
Whole genome deep sequencing of many longitudinally sampled HIV-1 populations reveals that reversions towards ancestral HIV-1 genome sequences occur throughout the course of infection.
Zoulfia Darieva, Aaron Webber ... Andrew D Sharrocks
Chromatin structure is altered following DNA replication stress through the activity of protein kinase C signalling which leads to functionally coupled histone H3 phosphorylation and acetylation events.
The newly discovered Titin internal promoter may explain why the severity of dilated cardiomyopathy in patients with truncating mutations in Titin varies dramatically depending on position of the mutation.
