Browse our latest Genetics and Genomics articles

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    1. Genetics and Genomics

    Explaining the counter-intuitive effectiveness of trophectoderm biopsy for PGT-A using computational modelling

    Benjamin M Skinner, Manuel Viotti ... Peter JI Ellis
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Genetics and Genomics

    Deciphering the complex relationship between type 2 diabetes and fracture risk with both genetic and observational evidence

    Pianpian Zhao, Zhifeng Sheng ... Hou-Feng Zheng
    Genetically determined type 2 diabetes (T2D) may not increase the risk of fracture, but managing T2D-related risk factors is crucial to prevent fracture in patients with T2D.
    1. Genetics and Genomics

    The BTB-ZF gene Bm-mamo regulates pigmentation in silkworm caterpillars

    Songyuan Wu, Xiaoling Tong ... Fangyin Dai
    The BTB zinc finger gene Bm-mamo regulates melanin pigmentation in silkworm caterpillars from multiple aspects, including melanin synthesis, pigment granules maturation, and cuticle construction.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Single-cell ‘omic profiles of human aortic endothelial cells in vitro and human atherosclerotic lesions ex vivo reveal heterogeneity of endothelial subtype and response to activating perturbations

    Maria L Adelus, Jiacheng Ding ... Casey E Romanoski
    Primary endothelial cell cultures contain markedly heterogeneous cell subtypes that exhibit distinct molecular responses to disease-relevant exposures.
    1. Developmental Biology
    2. Genetics and Genomics

    Disruption in CYLC1 leads to acrosome detachment, sperm head deformity, and male in/subfertility in humans and mice

    Hui-Juan Jin, Yong Fan ... Su-Ren Chen
    Cylicin-1, a perinuclear theca protein, is critical for acrosome attachment and sperm head morphology.
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Immune Response: Investigating the role of vitamin D in asthma

    Siddhant Sharma, Mayank Garg
    Results in mice suggest that vitamin D reduces the symptoms of asthma by controlling an immune response that leads to inflammation of the airways.
    Version of Record
    Insight
    1. Genetics and Genomics

    Expanding the Drosophila toolkit for dual control of gene expression

    Jonathan Zirin, Barbara Jusiak ... Norbert Perrimon
    A CRISPR knock-in approach enables the efficient generation of tissue-specific LexA and QF driver lines which can simultaneously control gene expression in multiple tissues.
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Vitamin D constrains inflammation by modulating the expression of key genes on Chr17q12-21.1

    Ayse Kilic, Arda Halu ... Scott T Weiss
    Vitamin D regulates two human chromosomal loci, Chr17q12-21.1 and Chr17q21.2, that are associated with autoimmune and chronic inflammatory diseases.
    1. Genetics and Genomics

    Meta-Research: Understudied genes are lost in a leaky pipeline between genome-wide assays and reporting of results

    Reese Richardson, Heliodoro Tejedor Navarro ... Thomas Stoeger
    Find My Understudied Genes (FMUG) is a data-driven tool created to counteract the abandonment of understudied genes in -omics research.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Vascular Endothelium: More than just a simple barrier

    Erandi Velazquez-Miranda, Ming He
    Endothelial cell subpopulations are characterized by unique gene expression profiles, epigenetic landscapes and functional properties.
    Version of Record
    Insight