Browse our latest Genetics and Genomics articles

Page 90 of 143
    1. Evolutionary Biology
    2. Genetics and Genomics

    Recurrent evolution of high virulence in isolated populations of a DNA virus

    Tom Hill, Robert L Unckless
    The same host–virus interactions can evolve multiple times in nature, due to the high effective mutation rate of viruses, and provide interesting systems of study.
    1. Genetics and Genomics
    2. Neuroscience

    High neural activity accelerates the decline of cognitive plasticity with age in Caenorhabditis elegans

    Qiaochu Li, Daniel-Cosmin Marcu ... Karl Emanuel Busch
    Chronic excitation of the Caenorhabditis elegans oxygen-sensing neurons alters calcium homeostasis to accelerate the decline of neural plasticity with age.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    The deubiquitylase Ubp15 couples transcription to mRNA export

    Fanny Eyboulet, Célia Jeronimo ... François Robert
    Ubp15 regulates the ubiquitylation of the export adaptor Mex67.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Repression of interrupted and intact rDNA by the SUMO pathway in Drosophila melanogaster

    Yicheng Luo, Elena Fefelova ... Alexei A Aravin
    SUMO-dependent pathway is responsible for selective repression of damaged rDNA and silencing of intact surplus units revealing an epigenetic mechanism that controls the differential expression of identical sequences in the same cell.
    1. Genetics and Genomics

    Mutations primarily alter the inclusion of alternatively spliced exons

    Pablo Baeza-Centurion, Belén Miñana ... Ben Lehner
    Deep mutagenesis reveals that mutations rarely alter the inclusion of highly-included exons.
    1. Genetics and Genomics

    Genetic profiling of protein burden and nuclear export overload

    Reiko Kintaka, Koji Makanae ... Hisao Moriya
    A comprehensive analysis of yeast mutants has provided clues to understanding the physiological conditions caused by protein overexpression.
    1. Cell Biology
    2. Genetics and Genomics

    Cytoprotection by a naturally occurring variant of ATP5G1 in Arctic ground squirrel neural progenitor cells

    Neel S Singhal, Meirong Bai ... Dengke K Ma
    A genetic basis underlying cell resilience against metabolic stress in cells of a hibernator, Arctic ground squirrels, has been discovered.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Transcription termination and antitermination of bacterial CRISPR arrays

    Anne M Stringer, Gabriele Baniulyte ... Joseph T Wade
    Many bacteria use the Nus factor antitermination complex to prevent premature Rho-dependent transcription termination of their CRISPR arrays.
    1. Developmental Biology
    2. Genetics and Genomics

    Smchd1 is a maternal effect gene required for genomic imprinting

    Iromi Wanigasuriya, Quentin Gouil ... Marnie E Blewitt
    Imprinted gene expression is set up during a critical window of early embryonic development, by the translation of parental imprints by oocyte-supplied Smchd1 into allele-specific gene silencing.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    A rat epigenetic clock recapitulates phenotypic aging and co-localizes with heterochromatin

    Morgan Levine, Ross A McDevitt ... Luigi Ferrucci
    The first epigenetic clock for rats was developed and revealed to reflect phenotypic aging and captured the effects of longevity interventions.