Genome editing in the choanoflagellate Salpingoeca rosetta opens newfound possibilities to functionally probe choanoflagellate genes that may illuminate the origin of their closest relatives, the animals.
Benjamin W Okaty, Nikita Sturrock ... Susan M Dymecki
Dorsal raphe Pet1 neurons are molecularly heterogeneous, comprising as many as fourteen distinct subtypes that show biased cell body distributions across dorsal raphe subdomains.
Zachary D Blount, Rohan Maddamsetti ... Richard E Lenski
Transposable elements and gene amplifications can provide variation needed for novel trait refinement and adaptation to new niches, though a recalcitrant organism-environment mismatch may persist.
Stephan Kamrad, María Rodríguez-López ... Jürg Bähler
An open-source python package for phenotype analyses provides a versatile, modular and user-friendly solution to determine complementary fitness-related traits from large-scale assays of microbial colonies.
Unbiased ChIP-seq screens and genetic knockouts of large Kruppel associated box zinc finger protein (KRAB-ZFP) clusters reveal that evolutionarily young KRAB-ZFPs play a redundant role in retrotransposon restriction in mice.
Transcriptomic and genetic analyses of FoxO target genes reveal a key function of ER-associated protein degradation in growth regulation of Tsc1-deficient tissues.
Olivier Serralbo, David Salgado ... Christophe Marcelle
Transfection of quail primordial germ cells considerably expands the possibilities of genome modifications in birds, elevating the quail to the rank of genetic laboratory animal models of reference.
Aisling Y Coughlan, Lisa Lombardi ... Kenneth H Wolfe
A family of homing genetic elements that look like inteins but work differently is the progenitor of the endonuclease that enables Saccharomyces cerevisiae to change its mating type.
