Browse our latest Genetics and Genomics articles

Page 96 of 143
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Expandable and reversible copy number amplification drives rapid adaptation to antifungal drugs

    Robert T Todd, Anna Selmecki
    Novel segmental chromosome amplifications in Candida albicans provide rapid adaptation to the most widely used antifungal drugs.
    1. Genetics and Genomics
    2. Medicine

    Does the human placenta express the canonical cell entry mediators for SARS-CoV-2?

    Roger Pique-Regi, Roberto Romero ... Nardhy Gomez-Lopez
    The human placenta negligibly co-expresses the transcripts encoding the canonical cell-entry mediators for SARS-CoV-2, which explains why mothers with COVID-19 rarely transmit the virus to the fetus.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Trait-associated noncoding variant regions affect TBX3 regulation and cardiac conduction

    Jan Hendrik van Weerd, Rajiv A Mohan ... Vincent M Christoffels
    Multiple variant transcriptional regulatory elements in >1 megabasepairs of noncoding DNA close to TBX3 affect gene expression and atrioventricular conduction system function in vivo.
    1. Genetics and Genomics

    A non-mosaic transchromosomic mouse model of Down syndrome carrying the long arm of human chromosome 21

    Yasuhiro Kazuki, Feng J Gao ... Roger H Reeves
    TcMAC21 is an appropriate “next gen” mouse model for DS research, and provides a proof of concept of using artificial chromosomes to generate non-mosaic humanized animal models of chromosome disorders.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Isolation and transcriptomic analysis of Anopheles gambiae oenocytes enables the delineation of hydrocarbon biosynthesis

    Linda Grigoraki, Xavier Grau-Bové ... Hilary Ranson
    Delineation of the cuticular hydrocarbon biosynthetic pathway in malaria vectors is a key step in understanding how mosquitoes adapt to anthropogenic change and vector control interventions.
    1. Cell Biology
    2. Genetics and Genomics

    A trans-eQTL network regulates osteoclast multinucleation and bone mass

    Marie Pereira, Jeong-Hun Ko ... Jacques Behmoaras
    MMnet is a conserved, trans-regulated gene network that controls skeletal homeostasis through osteoclast multinucleation and bone resorptive function.
    1. Genetics and Genomics

    Alternative polyadenylation mediates genetic regulation of gene expression

    Briana E Mittleman, Sebastian Pott ... Yang Li
    Genetic variation can impact multiple levels of gene regulation and disease through alternative polyadenylation.
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Evolutionarily conserved regulation of immunity by the splicing factor RNP-6/PUF60

    Chun Kew, Wenming Huang ... Adam Antebi
    The splicing factor RNP-6/PUF60 suppresses immunity by modulating host splicing and transcriptional responses to infection.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Predicting geographic location from genetic variation with deep neural networks

    CJ Battey, Peter L Ralph, Andrew D Kern
    Neural networks allow fast and accurate prediction of individual spatial locations from genotypes or sequencing data.
    1. Cell Biology
    2. Genetics and Genomics

    The histone modification reader ZCWPW1 links histone methylation to PRDM9-induced double-strand break repair

    Tao Huang, Shenli Yuan ... Hongbin Liu
    ZCWPW1 is a histone modification reader that localizes to DMC1-labelled double-strand break hotspots in a largely PRDM9-dependent manner, where it facilitates completion of synapsis by mediating DSB repair process.