Third SARS-CoV-2 vaccination appears to eliminate disparities in anti-Spike antibodies between those who received Pfizer-BioNTech versus Oxford/AstraZeneca for first and second vaccination, but levels remain lower in certain groups such as those on the UK 'Shielded Patient List'.
Compared to non-burn tissue, T cells in burn tissue have a pro-inflammatory rather than a homeostatic tissue-resident phenotype, and unconventional T cells in burn tissue have a higher cytotoxic capacity.
Fibroblast growth factor 21 blocks hepatic lipid influx and accumulation, prevents Kupffer cell activation, and inhibits the formation of hepatic lipid- and scar-associated macrophages, thereby likely inhibiting fibrogenesis in nonalcoholic steatohepatitis in humanized APOE*3-Leiden.CETP mice.
Investigating standard lag times prior to the pandemic and identifying key methodological considerations in lag time research can guide future investigations into the impact of time to care for patients with cancer.
Experiments on mice suggest that an approach called antisense oligonucleotide therapy may be able to treat some symptoms of Angelman syndrome, including problems with epilepsy and sleep.
Endocrine therapy after mastectomy may not be recommended for patients with hormone receptor positive ductal carcinoma in situ, even for those with high-risk factors.
Thomas H Julian, Johnathan Cooper-Knock ... Panagiotis I Sergouniotis
A phenome-wide Mendelian randomisation analysis revealed a causal link between age-related macular degeneration and a number of lipid, complement, immune cell, and serum protein traits, highlighting potential treatment targets.
