Browse our latest Medicine articles

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    1. Medicine

    Single-cell RNA sequencing and lineage tracing confirm mesenchyme to epithelial transformation (MET) contributes to repair of the endometrium at menstruation

    Phoebe M Kirkwood, Douglas A Gibson ... Philippa TK Saunders
    In a mouse model of menstruation stromal cells respond to breakdown of the tissue by changing their identity to become epithelial cells that are incorporated into the luminal epithelium which is rapidly 'healed' without scarring.
    1. Medicine
    2. Microbiology and Infectious Disease

    Efficacy of ultra-short, response-guided sofosbuvir and daclatasvir therapy for hepatitis C in a single-arm mechanistic pilot study

    Barnaby Flower, Le Manh Hung ... Graham S Cooke
    Shortened hepatitis C therapy, with retreatment if needed, can reduce antiviral drug use in patients with mild liver disease, but day 2 viral load is not an adequate predictor of outcome.
    1. Medicine

    Bone circuitry and interorgan skeletal crosstalk

    Mone Zaidi, Se-Min Kim ... Tony Yuen
    Intracellular and interorgan skeletal crosstalk highlights integrative skeletal physiology.
    1. Medicine
    2. Microbiology and Infectious Disease

    Sex and prior exposure jointly shape innate immune responses to a live herpesvirus vaccine

    Foo Cheung, Richard Apps ... Jeffrey I Cohen
    In a study of a herpes simplex virus (HSV) vaccine, the combination of sex and prior exposure to the virus resulted in HSV naive women mounting a prominent type I interferon response associated with reduced neutralizing titers to HSV.
    1. Medicine

    Is calcium a link between inflammatory bone resorption and heart disease?

    Gordon L Klein
    A mechanism is proposed that allows investigators to study interventions to delay onset of heart disease in patients suffering from chronic inflammatory disease with bone loss.
    1. Cancer Biology
    2. Medicine

    Procalcitonin for antimicrobial stewardship among cancer patients admitted with COVID-19

    Hiba Dagher, Anne-Marie Chaftari ... Issam Raad
    Procalcitonin could be useful in enhancing antimicrobial stewardship in cancer patients with COVID-19.
    1. Cell Biology
    2. Medicine

    Cellular features of localized microenvironments in human meniscal degeneration: a single-cell transcriptomic study

    Weili Fu, Sijie Chen ... Xuegong Zhang
    A single-cell transcriptome atlas reveals meniscal microenvironment variations during degeneration and cellular heterogeneity foundations of the inner–outer zone differences, suggesting novel cell subtypes as potential therapeutic targets.
    1. Developmental Biology
    2. Medicine

    Meta-Research: The need for more research into reproductive health and disease

    Natalie D Mercuri, Brian J Cox
    An analysis of publications and research grants shows that the volume of research on reproductive organs is much less than that on non-reproductive organs.
    1. Medicine
    2. Physics of Living Systems

    High spatial resolution analysis using automated indentation mapping differentiates biomechanical properties of normal vs. degenerated articular cartilage in mice

    Anand O Masson, Bryce Besler ... Roman J Krawetz
    The method presented here allows researchers to retrieve accurate and reproducible biomechanical properties of mouse cartilage.
    1. Epidemiology and Global Health
    2. Medicine

    Cardiovascular disease and subsequent risk of psychiatric disorders: a nationwide sibling-controlled study

    Qing Shen, Huan Song ... Unnur Valdimarsdóttir
    Patients diagnosed with a cardiovascular disease are at higher risk of psychiatric disorders, independent of familial factors shared between full siblings and comorbid conditions.