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    1. Immunology and Inflammation
    2. Medicine

    Immune dynamics in SARS-CoV-2 experienced immunosuppressed rheumatoid arthritis or multiple sclerosis patients vaccinated with mRNA-1273

    Niels JM Verstegen, Ruth R Hagen ... Carolien E van de Sandt
    SARS-CoV-2 experienced ocrelizumab-treated MS patients benefit from SARS-CoV-2 mRNA vaccination by inducing broadprotective CD8+ T-cells, whereas methotrexate-treated RA patients induce delayed but strong antibody responses, which support vaccine strategies for these patient groups.
    1. Medicine
    2. Microbiology and Infectious Disease

    Reconstruction of transmission chains of SARS-CoV-2 amidst multiple outbreaks in a geriatric acute-care hospital: a combined retrospective epidemiological and genomic study

    Mohamed Abbas, Anne Cori ... Stephan Harbarth
    Nosocomial transmission of SARS-Cov-2 in geriatric settings is complex, with different patterns between patients and healthcare workers working in Covid/non-Covid wards that should be taken into account when designing infection control strategies.
    1. Medicine

    Insights from full-text analyses of the Journal of the American Medical Association and the New England Journal of Medicine

    Moustafa Abdalla, Mohamed Abdalla ... Scott H Podolsky
    Historical analysis of nearly half-a-million articles from the Journal of the American Medical Association and the New England Journal of Medicine since their inception frames the shifting scientific, material, ethical, and epistemic underpinnings of medicine over time, including today.
    1. Genetics and Genomics
    2. Medicine

    Unbiased mosaic variant assessment in sperm: a cohort study to test predictability of transmission

    Martin W Breuss, Xiaoxu Yang ... Joseph G Gleeson
    The abundance of mosaic variants detected directly in sperm accurately predicts their transmission to concepti.
    1. Medicine

    Genomic landscape of lymphatic malformations: a case series and response to the PI3Kα inhibitor alpelisib in an N-of-1 clinical trial

    Montaser F Shaheen, Julie Y Tse ... Wadih Arap
    Pathogenic activating mutations in PIK3CA or NRAS were the most common genetic findings in a lymphatic malformation patient cohort and an N-of-1 trial of the PI3Kα inhibitor alpelisib in a patient with a PIK3CA mutation confirmed these findings are actionable.
    1. Epidemiology and Global Health
    2. Medicine

    Investigating the relationship of COVID-19 related stress and media consumption with schizotypy, depression, and anxiety in cross-sectional surveys repeated throughout the pandemic in Germany and the UK

    Sarah Daimer, Lorenz L Mihatsch ... Franziska Knolle
    The uncertainties of the pandemic and the restrictions on social life have a strong impact on mental well-being, and especially on the expression of schizotypal traits, which are further boosted by excessive media consumption.
    1. Cell Biology
    2. Medicine

    SNTA1 gene rescues ion channel function and is antiarrhythmic in cardiomyocytes derived from induced pluripotent stem cells from muscular dystrophy patients

    Eric N Jimenez-Vazquez, Michael Arad ... José Jalife
    Important mechanistic details on Duchenne Muscular Dystrophy arrhythmogenesis are revealed, providing a crucial lead for investigators interested in developing therapeutic solutions for this deadly disease.
    1. Medicine

    US women screen at low rates for both cervical and colorectal cancers than a single cancer: a cross-sectional population-based observational study

    Diane M Harper, Melissa Plegue ... Ananda Sen
    Only about half of women 50–64 years old are up-to-date for both cervical and colorectal cancer screening.
    1. Evolutionary Biology
    2. Medicine

    Evolution-based mathematical models significantly prolong response to abiraterone in metastatic castrate-resistant prostate cancer and identify strategies to further improve outcomes

    Jingsong Zhang, Jessica Cunningham ... Robert Gatenby
    Integration of evolutionary dynamics framed through a mathematical model improved outcomes in abiraterone monotherapy for the treatment of metastatic castrate-resistant prostate cancer.
    1. Medicine
    2. Neuroscience

    Altered excitatory and inhibitory neuronal subpopulation parameters are distinctly associated with tau and amyloid in Alzheimer’s disease

    Kamalini G Ranasinghe, Parul Verma ... Srikantan S Nagarajan
    Excitatory and inhibitory neuronal abnormalities show distinct associations to tau and amyloid accumulations in patients with Alzheimer’s disease.
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