Eva Herdering, Tristan Reif-Trauttmansdorff ... Ruth Anne Schmitz
The central nitrogen-metabolite 2-oxoglutarate directly promotes glutamine synthetase activity by inducing its dodecameric assembly and priming the active sites, representing a novel mechanism of regulation.
Ainhoa Arbués, Sarah Schmidiger ... Damien Portevin
Genetically diverse Mycobacterium tuberculosis complex strains induce a gamut of human granulomatous responses in vitro, with a role for IL-1β in aggregate formation.
Analysis of inflammasome responses in human macrophages reveals that inflammatory caspases and pyroptotic factors control Salmonella replication primarily within the cytosol and also within vacuoles.
Gabriel Magno de Freitas Almeida, Iker Arriaga ... Lotta-Riina Sundberg
Jyvaskylavirus, the northernmost isolate of the Marseilleviridae family, shows that giant viruses are also part of the boreal Finnish environment and brings structural information with relevance for understanding other viruses.
A combination of imaging techniques reveals how herpes simplex virus type 1 assembles within infected cells, highlighting the roles of essential viral proteins in viral assembly and exit.
