Browse our latest Microbiology and Infectious Disease articles

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    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    Viral Condensates: Making it hard to replicate

    Billy Wai-Lung Ng, Stephan Scheeff, Josefina Xeque Amada
    Understanding how to harden liquid condensates produced by influenza A virus could accelerate the development of novel antiviral drugs.
    Version of Record
    Insight
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    The evolution of colistin resistance increases bacterial resistance to host antimicrobial peptides and virulence

    Pramod K Jangir, Lois Ogunlana ... Craig R MacLean
    Resistance genes that spread as a result of the use of an antimicrobial peptide (colistin) in agriculture (MCR) protect bacteria against key components of human and animal immune systems.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Structural and regulatory insights into the glideosome-associated connector from Toxoplasma gondii

    Amit Kumar, Oscar Vadas ... Stephen Matthews
    The glideosome-associated connector protein transitions between open and closed states, and this regulates its assembly and function during apicomplexan parasite motility.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Characterisation of an Escherichia coli line that completely lacks ribonucleotide reduction yields insights into the evolution of parasitism and endosymbiosis

    Samantha DM Arras, Nellie Sibaeva ... Anthony M Poole
    An Escherichia coli line lacking deoxyribonucleotide synthesis has been created and subjected to experimental evolution, revealing that endosymbionts and pathogens that lack ribonucleotide reduction avoid loss of deoxyribonucleotides to central metabolism by disruption of the salvage pathway.
    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    An optimal regulation of fluxes dictates microbial growth in and out of steady state

    Griffin Chure, Jonas Cremer
    Microbial cells optimally structure their proteomes in order to mutually maximize metabolism and translation, as established by an extensive comparison between data and a low-dimensional model of cellular physiology.
    1. Microbiology and Infectious Disease

    Integration host factor regulates colonization factors in the bee gut symbiont Frischella perrara

    Konstantin Schmidt, Gonçalo Santos-Matos ... Philipp Engel
    Genes for adhesion, interbacterial competition, and secondary metabolite production are important colonization factors of the honey bee gut symbiont Frischella perrara and are regulated by the conserved histone-like DNA-binding protein integration host factor.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Viruses: How avian influenza viruses spill over to mammals

    Arturo Barbachano-Guerrero, Daniel R Perez, Sara L Sawyer
    The H3N2 canine influenza virus – which originally came from birds – is evolving to become more transmissible between dogs.
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    Insight
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Competition between lysogenic and sensitive bacteria is determined by the fitness costs of the different emerging phage-resistance strategies

    Olaya Rendueles, Jorge AM de Sousa, Eduardo PC Rocha
    The emergence and evolution of different phage-resistance strategies during coevolution between a phage-sensitive strain and a polylysogenic competitor depend on the amount of phage pressure, the fitness costs of resistance, and how these may change at different time scales.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Selection of HIV-1 for resistance to fifth-generation protease inhibitors reveals two independent pathways to high-level resistance

    Ean Spielvogel, Sook-Kyung Lee ... Ronald Swanstrom
    New HIV-1 protease inhibitor designs result in more potent inhibitors with high genetic barriers to resistance and the ability to lead virus evolution down less fit pathways when resistance occurs.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Rescue of Escherichia coli auxotrophy by de novo small proteins

    Arianne M Babina, Serhiy Surkov ... Michael Knopp
    De novo-generated small proteins can cause deattenuation of an amino acid biosynthetic operon by direct protein–RNA interactions.