Browse our latest Microbiology and Infectious Disease articles

Page 52 of 168
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Core genes can have higher recombination rates than accessory genes within global microbial populations

    Asher Preska Steinberg, Mingzhi Lin, Edo Kussell
    Homologous recombination rates tend to be highest in the most conserved parts of bacterial genomes.
    1. Microbiology and Infectious Disease

    Vaccination decreases the risk of influenza A virus reassortment but not genetic variation in pigs

    Chong Li, Marie R Culhane ... Montserrat Torremorell
    Vaccination has the potential to decrease swine influenza diversification by restricting influenza virus co-infections and reassortment events in pigs.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Temporal and thermal profiling of the Toxoplasma proteome implicates parasite Protein Phosphatase 1 in the regulation of Ca2+-responsive pathways

    Alice L Herneisen, Zhu-Hong Li ... Sebastian Lourido
    Time-resolved phosphoproteomics and thermal proteome profiling reveal the Ca2+-responsive proteome of the model apicomplexan Taxoplasma gondii, identifying PP1 as a Ca2+-responsive enzyme that regulates Ca2+ uptake to promote parasite motility.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Machine learning-assisted discovery of growth decision elements by relating bacterial population dynamics to environmental diversity

    Honoka Aida, Takamasa Hashizume ... Bei-Wen Ying
    A smart combination of machine learning and high-throughput data generation of bacterial population dynamics successfully leads to an intriguing finding of the differentiation in decision-making components for bacterial growth.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Pneumococcal genetic variability in age-dependent bacterial carriage

    Philip HC Kremer, Bart Ferwerda ... John A Lees
    Future vaccination strategies in pneumococcal disease should target specific bacterial serotypes for different host age groups.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    The evolution of a counter-defense mechanism in a virus constrains its host range

    Sriram Srikant, Chantal K Guegler, Michael T Laub
    Bacteriophage can rapidly evolve resistance to anti-phage defense elements in bacteria by amplifying latent counter-defense genes, though this amplification comes at a cost of compensatory deletions that eliminate other counter-defense genes.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    BIRC6 modifies risk of invasive bacterial infection in Kenyan children

    James J Gilchrist, Silvia N Kariuki ... Thomas N Williams
    Defining the probability of bacterial disease among children with severe malaria allows the integration of bacteraemia and severe malaria genome-wide association study data, identifying a novel risk locus for invasive bacterial disease.
    1. Microbiology and Infectious Disease

    Zika virus causes placental pyroptosis and associated adverse fetal outcomes by activating GSDME

    Zikai Zhao, Qi Li ... Jing Ye
    Zika virus infection induces the gasdermin E-mediated pyroptosis in placental cells through TNF-α-caspase-8-caspase-3 signaling pathway, which contributes to adverse fetal outcomes in pregnant mouse model.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Amoxicillin-resistant Streptococcus pneumoniae can be resensitized by targeting the mevalonate pathway as indicated by sCRilecs-seq

    Liselot Dewachter, Julien Dénéréaz ... Jan-Willem Veening
    High-throughput single-cell based, genome-wide gene silencing screening (sCRilecs-seq) revealed that drugging the mevalonate pathway resensitizes amoxicillin-resistant pneumococci.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Pre-existing chromosomal polymorphisms in pathogenic E. coli potentiate the evolution of resistance to a last-resort antibiotic

    Pramod K Jangir, Qiue Yang ... R Craig MacLean
    Interactions between a mobile resistance gene and chromosomal mutations drive the evolution of high-level antibiotic resistance.