Browse our latest Microbiology and Infectious Disease articles

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    1. Microbiology and Infectious Disease

    Critical roles for ‘housekeeping’ nucleases in type III CRISPR-Cas immunity

    Lucy Chou-Zheng, Asma Hatoum-Aslan
    Genetic and biochemical analyses reveal that the bacterial nucleases PNPase and RNase R work in concert with a type III-A CRISPR-Cas immune system to process small CRISPR RNAs and ensure robust immunity against foreign nucleic acid invaders.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Evidence linking APOBEC3B genesis and evolution of innate immune antagonism by gamma-herpesvirus ribonucleotide reductases

    Sofia N Moraes, Jordan T Becker ... Reuben S Harris
    The birth of the antiviral gene APOBEC3B in ancient primates is linked to the evolution of a potent counterdefense by herpesviruses, a host-pathogen interaction maintained to present day.
    1. Microbiology and Infectious Disease

    Glutamine synthetase mRNA releases sRNA from its 3′UTR to regulate carbon/nitrogen metabolic balance in Enterobacteriaceae

    Masatoshi Miyakoshi, Teppei Morita ... Kan Tanaka
    Under nitrogen limitation, Salmonella and Escherichia coli express a messenger RNA to translate glutamine synthetase, and concomitantly the messenger RNA produces a small RNA from its 3′ end to inhibit the translation of 2-oxoglutarate dehydrogenase of the TCA cycle.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    The clinical pharmacology of tafenoquine in the radical cure of Plasmodium vivax malaria: An individual patient data meta-analysis

    James A Watson, Robert J Commons ... Nicholas J White
    The currently recommended adult dose of tafenoquine is insufficient for radical cure in all adults.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    COVID-19 cluster size and transmission rates in schools from crowdsourced case reports

    Paul Tupper, Shraddha Pai ... Caroline Colijn
    Fitting a simple model of COVID-19 transmission to crowdsourced case report data allowed the estimation of mean cluster size and transmission rates in Canadian schools, as well as determining which interventions are most likely to limit transmission.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    The RAM signaling pathway links morphology, thermotolerance, and CO2 tolerance in the global fungal pathogen Cryptococcus neoformans

    Benjamin J Chadwick, Tuyetnhu Pham ... Xiaorong Lin
    In the fungal pathogen Cryptococcus neoformans, the RAM pathway, potentially through post-transcriptional regulation, plays an essential role in adaptation to host temperature and CO2.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Science Forum: A low-cost, open-source evolutionary bioreactor and its educational use

    Vishhvaan Gopalakrishnan, Dena Crozier ... Jacob G Scott
    The EVolutionary biorEactor (EVE) can be built for less than $200, and can be used to evaluate microbial population dynamics in the lab and to teach evolution in high schools.
    1. Ecology
    2. Microbiology and Infectious Disease

    Variation in the ACE2 receptor has limited utility for SARS-CoV-2 host prediction

    Nardus Mollentze, Deborah Keen ... Daniel G Streicker
    The success of angiotensin-converting enzyme 2 (ACE2)-based predictions of severe acute respiratory syndrome-associated virus 2 (SARS-CoV-2) host range stems from phylogenetic correlation, allowing development of scalable models which predict susceptibility to SARS-CoV-2 and other sarbecoviruses without requiring additional ACE2 sequencing.
    1. Microbiology and Infectious Disease
    2. Plant Biology

    Acetylation of a fungal effector that translocates host PR1 facilitates virulence

    Jingtao Li, Xiaoying Ma ... Wenxing Liang
    Acetylation stabilizes a fungal effector to mis-localize a key defense protein, leading to compromised immunity of host plants.
    1. Microbiology and Infectious Disease

    An essential periplasmic protein coordinates lipid trafficking and is required for asymmetric polar growth in mycobacteria

    Kuldeepkumar R Gupta, Celena M Gwin ... E Hesper Rego
    Asymmetric growth in mycobacteria requires a protein that is involved in trafficking mycolic acids to the outer membrane.
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