Browse our latest Microbiology and Infectious Disease articles

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    1. Microbiology and Infectious Disease

    T cell deficiency precipitates antibody evasion and emergence of neurovirulent polyomavirus

    Matthew D Lauver, Ge Jin ... Aron E Lukacher
    Loss of T cell control during persistent polyomavirus infection, in the setting of a limited antiviral antibody response, facilitates emergence of antibody-escape viruses carrying the potential for neurovirulence.
    1. Microbiology and Infectious Disease

    Phage resistance profiling identifies new genes required for biogenesis and modification of the corynebacterial cell envelope

    Amelia C McKitterick, Thomas G Bernhardt
    Using bacteriophages as probes, new genes involved in cell surface construction were identified in a class of bacteria that includes important pathogens like Mycobacterium tuberculosis.
    1. Microbiology and Infectious Disease
    2. Neuroscience

    A prebiotic diet modulates microglial states and motor deficits in α-synuclein overexpressing mice

    Reem Abdel-Haq, Johannes CM Schlachetzki ... Sarkis K Mazmanian
    Microbiome-diet interactions shape microglia reactivity in a mouse model of Parkinson's disease.
    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    High-throughput imaging and quantitative analysis uncovers the nature of plasmid positioning by ParABS

    Robin Köhler, Eugen Kaganovitch, Seán M Murray
    The ParABS system positions plasmids precisely within the cell but just below the threshold for oscillatory dynamics.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Antiviral function and viral antagonism of the rapidly evolving dynein activating adaptor NINL

    Donté Alexander Stevens, Christopher Beierschmitt ... Matthew D Daugherty
    Evolution-guided functional analyses identify an activating adaptor of the dynein intracellular transportation machinery, NINL, as a novel component of the antiviral immune response and reveal a mechanism by which viruses antagonize NINL function in a species-specific manner.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    CD169+ macrophages orchestrate plasmacytoid dendritic cell arrest and retention for optimal priming in the bone marrow of malaria-infected mice

    Jamie Moore-Fried, Mahinder Paul ... Gregoire Lauvau
    CD169+ macrophages in the bone marrow of malaria-infected mice uptake infected red blood cells, and establish a functional interaction that is required to activate plasmacytoid dendritic cells to secrete type I interferon and leave the bone marrow.
    1. Microbiology and Infectious Disease

    Convergence of two global regulators to coordinate expression of essential virulence determinants of Mycobacterium tuberculosis

    Hina Khan, Partha Paul ... Dibyendu Sarkar
    The two global regulators CRP and PhoP interact with each other to coordinate expression of essential virulence determinants of Mycobacterium tuberculosis.
    1. Microbiology and Infectious Disease

    Mobilome-driven segregation of the resistome in biological wastewater treatment

    Laura de Nies, Susheel Bhanu Busi ... Paul Wilmes
    Biological wastewater treatment plants are critical reservoirs of antimicrobial resistance (AMR), allowing for early detection and monitoring of resistant pathogens, whilst serving as models for understanding the segregation of mobile genetic elements through AMR.
    1. Microbiology and Infectious Disease

    Targeted genomic sequencing with probe capture for discovery and surveillance of coronaviruses in bats

    Kevin S Kuchinski, Kara D Loos ... Andrew DS Cameron
    Hybridization probe capture is useful for discovery and surveillance of novel coronaviruses, and its unique strengths complement existing methods like amplicon sequencing and deep metagenomic sequencing.
    1. Ecology
    2. Microbiology and Infectious Disease

    Gastrointestinal helminths increase Bordetella bronchiseptica shedding and host variation in supershedding

    Nhat TD Nguyen, Ashutosh K Pathak, Isabella M Cattadori
    Helminth infected hosts are an important cause of variation in the level, frequency and duration of Bordetella bronchiseptica shedding and dynamics of infection.