Browse our latest Microbiology and Infectious Disease articles

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    1. Microbiology and Infectious Disease

    Legionella pneumophila modulates host energy metabolism by ADP-ribosylation of ADP/ATP translocases

    Jiaqi Fu, Mowei Zhou ... Zhao-Qing Luo
    Legionella pneumophila modulates host energy metabolism by targeting the ADP/ATP translocase carrier proteins with an effector of ADP-ribosyltransferase activity.
    1. Microbiology and Infectious Disease

    Sensitizing Staphylococcus aureus to antibacterial agents by decoding and blocking the lipid flippase MprF

    Christoph J Slavetinsky, Janna N Hauser ... Andreas Peschel
    Blocking the bacterial lipid flippase MprF by monoclonal antibodies enhance staphylococcal clearance by host defense and antibiotics providing a novel proof of concept for antivirulence approaches targeting bacterial resistance mechanisms.
    1. Microbiology and Infectious Disease

    An intestinally secreted host factor promotes microsporidia invasion of C. elegans

    Hala Tamim El Jarkass, Calvin Mok ... Aaron W Reinke
    A forward genetic screen in Caenorhabditis elegans identifies a secreted host protein that ensures proper microsporidia spore orientation, resulting in efficient invasion of intestinal cells.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Structural basis of malaria transmission blockade by a monoclonal antibody to gamete fusogen HAP2

    Juan Feng, Xianchi Dong ... Timothy A Springer
    Structures of a gamete fusogen and antibody fragments bound to its domain 3, and inhibition of parasite fertilization, bring us closer to creating a vaccine to block transmission by mosquitoes of malaria from one person to another.
    1. Microbiology and Infectious Disease

    Comment on ‘Unexpected plasticity in the life cycle of Trypanosoma brucei

    Keith R Matthews, Stephen Larcombe
    We are writing to comment on the article by Schuster et al., 2021 about the life cycle of Trypanosoma brucei.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Response to comment on 'Unexpected plasticity in the life cycle of Trypanosoma Brucei'

    Jaime Lisack, Brooke Morriswood, Markus Engstler
    We are writing to respond to the comment by Matthews and Larcombe, 2022 on our article about the life cycle of Trypanosoma brucei (Schuster et al., 2021).
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Stress conditions promote Leishmania hybridization in vitro marked by expression of the ancestral gamete fusogen HAP2 as revealed by single-cell RNA-seq

    Isabelle Louradour, Tiago Rodrigues Ferreira ... David Sacks
    Following exposure of Leishmania culture promastigotes to DNA stress, single-cell RNA sequencing reveals discrete clusters of cells associated with efficient generation of hybrids between different species and strains in vitro marked by expression of the ancestral gamete fusogen HAP2.
    1. Microbiology and Infectious Disease

    Golden Syrian hamster as a model to study cardiovascular complications associated with SARS-CoV-2 infection

    Zaigham Abbas Rizvi, Rajdeep Dalal ... Amit Awasthi
    SARS-CoV-2 infection in hamsters causes cardiovascular pathologies.
    1. Microbiology and Infectious Disease

    Multi-omics investigation of Clostridioides difficile-colonized patients reveals pathogen and commensal correlates of C. difficile pathogenesis

    Skye RS Fishbein, John I Robinson ... Gautam Dantas
    Integration of clinical patient data, pathogen information and a multi-omic analysis of the gut microbiome reveals key determinants of disease in C. difficile-colonized patients.
    1. Microbiology and Infectious Disease

    A qnr-plasmid allows aminoglycosides to induce SOS in Escherichia coli

    Anamaria Babosan, David Skurnik ... Thomas Guillard
    A mechanism whereby aminoglycosides-mediated SOS induction in Escherichia coli also promote high-level fluoroquinolone resistance.